"P(GP525/05/P160), Z(MSM0021622412)" . "Interference of N-heterocyclic PAHs with signaling of retinoids" . "Pachern\u00EDk, Ji\u0159\u00ED" . "Ben\u00ED\u0161ek, Martin" . "[F944F6260C66]" . . . . . . . . . . "14310" . "Bl\u00E1ha, Lud\u011Bk" . . . . . . "Interference of N-heterocyclic PAHs with signaling of retinoids"@en . . . . "N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160."@en . "N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160." . "RIV/00216224:14310/07:00020348!RIV11-GA0-14310___" . "Interference of N-heterocyclic PAHs with signaling of retinoids" . "4"^^ . "Interference of N-heterocyclic PAHs with signaling of retinoids"@en . . "4"^^ . . "RIV/00216224:14310/07:00020348" . "retinoid; N-PAHs; in vitro"@en . "427153" . "Hilscherov\u00E1, Kl\u00E1ra" . .