"Aktivita dioxinov\u00E9ho typu u modelov\u00FDch sm\u011Bs\u00ED polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F"@cs . "978-80-88870-64-7" . . . "Ben\u00ED\u0161ek, Martin" . "This study presents dioxin-like activities of defined mixtures of polycyclic aromatic hydrocarbons"@en . "P(GP525/05/P160)" . "\u0160tudentsk\u00E1 vedeck\u00E1 konferencia, 1.zv\u00E4zok, biologick\u00E1 a environment\u00E1lna sekcia" . "dioxin-like activity; PAHs; mixtures"@en . "Univerzita Komensk\u00E9ho v Bratislave" . "[BE9DFD4AE92D]" . . "2007-04-18+02:00"^^ . "Hilscherov\u00E1, Kl\u00E1ra" . . "V\u011Bt\u0161ina toxikologick\u00FDch studi\u00ED se v sou\u010Dasnosti zam\u011B\u0159uje pouze na efekty jednotliv\u00FDch chemick\u00FDch l\u00E1tek, v p\u0159\u00EDrod\u011B jsou v\u0161ak organismy v\u011Bt\u0161inou vystaveny komplexn\u00EDm environment\u00E1ln\u00EDm sm\u011Bs\u00EDm. Jednotliv\u00E9 l\u00E1tky ve sm\u011Bsi mohou p\u016Fsobit bu\u010F zcela nez\u00E1visle, nebo stejn\u00FDm zp\u016Fsobem a vytv\u00E1\u0159et tak aditivn\u00ED, antagonistick\u00E9 nebo synergistick\u00E9 \u00FA\u010Dinky. Cel\u00E1 \u0159ada environment\u00E1ln\u00EDch sm\u011Bs\u00ED obsahuje mno\u017Estv\u00ED l\u00E1tek, kter\u00E9 aktivuj\u00ED arylhydrokarbonov\u00FD receptor (AhR). Mezi tyto l\u00E1tky pat\u0159\u00ED p\u0159edev\u0161\u00EDm polycyklick\u00E9 aromatick\u00E9 uhlovod\u00EDky (PAHs), polychlorovan\u00E9 dioxiny, dibenzofurany nebo polychlorovan\u00E9 bifenyly [1]. Mezi nep\u0159\u00EDzniv\u00E9 efekty spojen\u00E9 s aktivac\u00ED Ah receptoru pat\u0159\u00ED nap\u0159\u00EDklad imunotoxicita, v\u00FDvojov\u00E1 a reproduk\u010Dn\u00ED toxicita, nebo karcinogenita [2]. V t\u00E9to studii jsme se zam\u011B\u0159ili na zji\u0161t\u011Bn\u00ED vlivu sm\u011Bs\u00ED na aktivaci AhR, kter\u00E1 byla stanovena na bun\u011B\u010Dn\u00E9 linii H4IIE.luc. Jedn\u00E1 se o modern\u00ED in vitro test vyu\u017E\u00EDvaj\u00EDc\u00ED transgenn\u00EDch bun\u011Bk krys\u00EDho hepatomu, do jejich\u017E DNA byl vlo\u017Een gen pro tvorbu lucifer\u00E1zy." . . . "Aktivita dioxinov\u00E9ho typu u modelov\u00FDch sm\u011Bs\u00ED polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F" . . "Dioxin-like activity of defined mixtures of polycyclic aromatic hydrocarbons"@en . . "\u0160t\u011Bp\u00E1nkov\u00E1, Tereza" . "Dioxin-like activity of defined mixtures of polycyclic aromatic hydrocarbons"@en . . "Aktivita dioxinov\u00E9ho typu u modelov\u00FDch sm\u011Bs\u00ED polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F"@cs . "Aktivita dioxinov\u00E9ho typu u modelov\u00FDch sm\u011Bs\u00ED polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F" . "V\u011Bt\u0161ina toxikologick\u00FDch studi\u00ED se v sou\u010Dasnosti zam\u011B\u0159uje pouze na efekty jednotliv\u00FDch chemick\u00FDch l\u00E1tek, v p\u0159\u00EDrod\u011B jsou v\u0161ak organismy v\u011Bt\u0161inou vystaveny komplexn\u00EDm environment\u00E1ln\u00EDm sm\u011Bs\u00EDm. Jednotliv\u00E9 l\u00E1tky ve sm\u011Bsi mohou p\u016Fsobit bu\u010F zcela nez\u00E1visle, nebo stejn\u00FDm zp\u016Fsobem a vytv\u00E1\u0159et tak aditivn\u00ED, antagonistick\u00E9 nebo synergistick\u00E9 \u00FA\u010Dinky. Cel\u00E1 \u0159ada environment\u00E1ln\u00EDch sm\u011Bs\u00ED obsahuje mno\u017Estv\u00ED l\u00E1tek, kter\u00E9 aktivuj\u00ED arylhydrokarbonov\u00FD receptor (AhR). Mezi tyto l\u00E1tky pat\u0159\u00ED p\u0159edev\u0161\u00EDm polycyklick\u00E9 aromatick\u00E9 uhlovod\u00EDky (PAHs), polychlorovan\u00E9 dioxiny, dibenzofurany nebo polychlorovan\u00E9 bifenyly [1]. Mezi nep\u0159\u00EDzniv\u00E9 efekty spojen\u00E9 s aktivac\u00ED Ah receptoru pat\u0159\u00ED nap\u0159\u00EDklad imunotoxicita, v\u00FDvojov\u00E1 a reproduk\u010Dn\u00ED toxicita, nebo karcinogenita [2]. V t\u00E9to studii jsme se zam\u011B\u0159ili na zji\u0161t\u011Bn\u00ED vlivu sm\u011Bs\u00ED na aktivaci AhR, kter\u00E1 byla stanovena na bun\u011B\u010Dn\u00E9 linii H4IIE.luc. Jedn\u00E1 se o modern\u00ED in vitro test vyu\u017E\u00EDvaj\u00EDc\u00ED transgenn\u00EDch bun\u011Bk krys\u00EDho hepatomu, do jejich\u017E DNA byl vlo\u017Een gen pro tvorbu lucifer\u00E1zy."@cs . . "Bratislava" . "Bratislava" . . . "3"^^ . "RIV/00216224:14310/07:00020346!RIV10-GA0-14310___" . "408850" . "RIV/00216224:14310/07:00020346" . "3"^^ . . "14310" . "3"^^ . . . . . .