"2"^^ . "14310" . "19"^^ . . . "2"^^ . . "Attention-deficit hyperactivity disorder (ADHD) belongs to common causes of psychiatric treatment in childhood. Risk factors of the pathogenesis are not only genetic factors, but also non-genetic ones such as low weight at birth, perinatal hypoxia and influence of toxic substancies during the prenatal period. The causes of the disorder have been thoroughly investigated using the neuroimaging and molecular biology methods in the past ten years. It was found that biological parents and relatives with ADHD have much higher percentage of ADHD symptoms in their offsprings. Obviously, the results of twin studies have brought the evidence of the disorders heritability. During the past few years many molecular-biology studies have appeared, which are focused on the research of influence of so-called candidate genes in the pathogenesis of ADHD. Our review summarises the results of these studies."@en . "Hyperkinetick\u00E1 porucha pat\u0159\u00ED k nej\u010Dast\u011Bj\u0161\u00EDm p\u0159\u00ED\u010Din\u00E1m psychiatrick\u00E9 l\u00E9\u010Dby v d\u011Btsk\u00E9m v\u011Bku. K rizikov\u00FDm faktor\u016Fm patogeneze hyperkinetick\u00E9 poruchy pat\u0159\u00ED nejen faktory genetick\u00E9, ale i faktory negenetick\u00E9 jako je n\u00EDzk\u00E1 porodn\u00ED v\u00E1ha, perinat\u00E1ln\u00ED hypoxie \u010Di vliv toxick\u00FDch l\u00E1tek v prenat\u00E1ln\u00EDm obdob\u00ED. P\u0159\u00ED\u010Diny onemocn\u011Bn\u00ED jsou v posledn\u00EDm desetilet\u00ED intenzivn\u011B hled\u00E1ny za vyu\u017Eit\u00ED neurozobrazovac\u00EDch metod a metod molekul\u00E1rn\u011B-biologick\u00FDch. V genetick\u00FDch studi\u00EDch bylo zji\u0161t\u011Bno, \u017Ee biologi\u010Dt\u00ED rodi\u010De a p\u0159\u00EDbuzn\u00ED s ADHD maj\u00ED mnohon\u00E1sobn\u011B vy\u0161\u0161\u00ED procento mo\u017En\u00E9ho v\u00FDskytu symptom\u016F hyperaktivity u sv\u00FDch d\u011Bt\u00ED. D\u016Fkazem heritability hyperkinetick\u00E9 poruchy jsou i v\u00FDsledky studi\u00ED dvoj\u010Dat. B\u011Bhem posledn\u00EDch deseti let se d\u00EDky rozmachu molekul\u00E1rn\u00ED biologie objevily mnoh\u00E9 studie, kter\u00E9 jsou zam\u011B\u0159eny na v\u00FDzkum vlivu tzv. kandid\u00E1tn\u00EDch gen\u016F na patogenezi hyperkinetick\u00E9 poruchy. Na\u0161e pr\u00E1ce v\u00FDsledky t\u011Bchto studi\u00ED p\u0159ehledn\u011B shrnuje." . . . "Hyperkinetick\u00E1 porucha pat\u0159\u00ED k nej\u010Dast\u011Bj\u0161\u00EDm p\u0159\u00ED\u010Din\u00E1m psychiatrick\u00E9 l\u00E9\u010Dby v d\u011Btsk\u00E9m v\u011Bku. K rizikov\u00FDm faktor\u016Fm patogeneze hyperkinetick\u00E9 poruchy pat\u0159\u00ED nejen faktory genetick\u00E9, ale i faktory negenetick\u00E9 jako je n\u00EDzk\u00E1 porodn\u00ED v\u00E1ha, perinat\u00E1ln\u00ED hypoxie \u010Di vliv toxick\u00FDch l\u00E1tek v prenat\u00E1ln\u00EDm obdob\u00ED. P\u0159\u00ED\u010Diny onemocn\u011Bn\u00ED jsou v posledn\u00EDm desetilet\u00ED intenzivn\u011B hled\u00E1ny za vyu\u017Eit\u00ED neurozobrazovac\u00EDch metod a metod molekul\u00E1rn\u011B-biologick\u00FDch. V genetick\u00FDch studi\u00EDch bylo zji\u0161t\u011Bno, \u017Ee biologi\u010Dt\u00ED rodi\u010De a p\u0159\u00EDbuzn\u00ED s ADHD maj\u00ED mnohon\u00E1sobn\u011B vy\u0161\u0161\u00ED procento mo\u017En\u00E9ho v\u00FDskytu symptom\u016F hyperaktivity u sv\u00FDch d\u011Bt\u00ED. D\u016Fkazem heritability hyperkinetick\u00E9 poruchy jsou i v\u00FDsledky studi\u00ED dvoj\u010Dat. B\u011Bhem posledn\u00EDch deseti let se d\u00EDky rozmachu molekul\u00E1rn\u00ED biologie objevily mnoh\u00E9 studie, kter\u00E9 jsou zam\u011B\u0159eny na v\u00FDzkum vlivu tzv. kandid\u00E1tn\u00EDch gen\u016F na patogenezi hyperkinetick\u00E9 poruchy. Na\u0161e pr\u00E1ce v\u00FDsledky t\u011Bchto studi\u00ED p\u0159ehledn\u011B shrnuje."@cs . "CZ - \u010Cesk\u00E1 republika" . . . . "\u0160taif, Radim" . . . . "Neurobiologie hyperkinetick\u00E9 poruchy"@cs . . . . . . . "1" . "[90514C44D63C]" . "Neurobiology of ADHD"@en . . . . "RIV/00216224:14310/07:00019002!RIV10-MZ0-14310___" . "Neurobiologie hyperkinetick\u00E9 poruchy" . "103" . . "P(NR9298), Z(MSM0021622413)" . "Neurobiology of ADHD"@en . . "\u010Cesk\u00E1 a slovensk\u00E1 psychiatrie" . . . "ADHD; hyperkinetic disorder; association study; polymorphism; gene; DRD2; DRD4; COMT; DBH; DAT1; NET1; MAO; IL-6"@en . "Neurobiologie hyperkinetick\u00E9 poruchy"@cs . "436993" . . "Neurobiologie hyperkinetick\u00E9 poruchy" . "1212-0383" . "RIV/00216224:14310/07:00019002" . "\u0160er\u00FD, Omar" . . . .