"6"^^ . "Paterson, Ian" . "Angewandte Chemie International Edition" . . "1433-7851" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A."@en . "Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A." . . "14310" . "The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide"@en . . "[FA9EA57533FF]" . . . . . "1"^^ . . "The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide" . . "RIV/00216224:14310/06:00032342" . . "7"^^ . "Meiler, Jens" . . "conformation analysis; discodermolide; NMR spectroscopy; structure-activity relationships; tubulin"@en . "The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide"@en . . "RIV/00216224:14310/06:00032342!RIV10-MSM-14310___" . . "Kub\u00ED\u010Dek, Karel" . "45" . "44" . "The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide" . "Carlomagno, Teresa" . "504522" . "V" . . . "Lyothier, Isabelle" . . "Sanchez-Pedregal, Victor M" .