"\u0160poner, Ji\u0159\u00ED" . . "Nils, Walter" . "[F15723AE749A]" . "6"^^ . "R\u00E9blov\u00E1, Kamila" . . . "RIV/00216224:14310/06:00017097" . . . . "Trapped water molecules are essential to structural dynamics and function of a ribozyme"@en . "504308" . "Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network." . . "103" . . "36" . . . "The Proceedings of the National Academy of Sciences" . . . . "Trapped water molecules are essential to structural dynamics and function of a ribozyme" . . . . "Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network."@en . . "CZ - \u010Cesk\u00E1 republika" . "14310" . "coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire"@en . . "RIV/00216224:14310/06:00017097!RIV10-MSM-14310___" . . "Rhodes, Maria" . . "2"^^ . . "Trapped water molecules are essential to structural dynamics and function of a ribozyme"@en . "1091-6490" . . "P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC06030), P(LC512), Z(AV0Z40550506), Z(AV0Z50040507), Z(MSM0021622413)" . "4"^^ . . "Trapped water molecules are essential to structural dynamics and function of a ribozyme" . . .