. "Vliv posttransla\u010Dn\u00EDch modifikac\u00ED na funkci proteinu Bcl-2" . . "The effects of posttranslational modifications on function of the Bcl-2 protein"@en . "Slov\u00E1\u010Dkov\u00E1, Jana" . . "5" . "Vliv posttransla\u010Dn\u00EDch modifikac\u00ED na funkci proteinu Bcl-2" . . . "CZ - \u010Cesk\u00E1 republika" . "RIV/00216224:14310/06:00016957" . . . "4"^^ . "Vliv posttransla\u010Dn\u00EDch modifikac\u00ED na funkci proteinu Bcl-2"@cs . . "The effects of posttranslational modifications on function of the Bcl-2 protein"@en . "0009-2770" . . . "1"^^ . . "4"^^ . . . "RIV/00216224:14310/06:00016957!RIV09-GA0-14310___" . "Bcl-2; apoptosis; cell differentiation; phosphorylation"@en . . "BM2 monoblasts overexpressing Bcl-2 exhibit low viability, condensed chromatin, nuclear fragmentation and DNA fragmentation. Our results suggest that the Bcl-2 protein undergoing post-translational modification by phosphorylation cannot interact with its protein partners thus loosing its capability to suppress apoptosis."@en . . "Ondrou\u0161kov\u00E1, Eva" . "Monoblasty BM2 se zv\u00FD\u0161enou hladinou BCl-2 vykazuj\u00ED sn\u00ED\u017Eenou \u017Eivotaschopnost, obsahuj\u00ED kondenzovan\u00FD chromatin, fragmentovan\u00E1 j\u00E1dra a jejich DNA podl\u00E9h\u00E1 \u0161t\u011Bpen\u00ED mezi nukleozomy. Z na\u0161ich v\u00FDsledk\u016F vypl\u00FDv\u00E1, \u017Ee protein Bcl-2 podl\u00E9h\u00E1 posttransla\u010Dn\u00ED modifikaci fosforylac\u00ED a tak ztr\u00E1c\u00ED svou schopnost interakce se sv\u00FDmi c\u00EDlov\u00FDmi proteiny. Patrn\u011B z toho d\u016Fvodu nen\u00ED schopen plnit svou anti-apoptotickou funkci."@cs . "14310" . "[5ECED5EAC2C1]" . . "\u0160marda, Jan" . "Pelkov\u00E1, Vendula" . . . "100" . "Chemick\u00E9 listy" . "Monoblasty BM2 se zv\u00FD\u0161enou hladinou BCl-2 vykazuj\u00ED sn\u00ED\u017Eenou \u017Eivotaschopnost, obsahuj\u00ED kondenzovan\u00FD chromatin, fragmentovan\u00E1 j\u00E1dra a jejich DNA podl\u00E9h\u00E1 \u0161t\u011Bpen\u00ED mezi nukleozomy. Z na\u0161ich v\u00FDsledk\u016F vypl\u00FDv\u00E1, \u017Ee protein Bcl-2 podl\u00E9h\u00E1 posttransla\u010Dn\u00ED modifikaci fosforylac\u00ED a tak ztr\u00E1c\u00ED svou schopnost interakce se sv\u00FDmi c\u00EDlov\u00FDmi proteiny. Patrn\u011B z toho d\u016Fvodu nen\u00ED schopen plnit svou anti-apoptotickou funkci." . . "Vliv posttransla\u010Dn\u00EDch modifikac\u00ED na funkci proteinu Bcl-2"@cs . . "P(GA301/06/0036), Z(MSM0021622415)" . . "506657" .