. "Sklen\u00E1\u0159, Vladim\u00EDr" . . . . . "Munzarov\u00E1, Mark\u00E9ta" . "Journal of the American Chemical Society" . "0002-7863" . . "128" . . "14310" . . "Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA." . "2"^^ . . . "Williamson, James R." . "RIV/00216224:14310/06:00016826" . . "17" . . "Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA."@en . "484543" . "Bermel, Wolfgang" . . "Hennig, Mirko" . "Scott, Lincol G." . "8"^^ . "RIV/00216224:14310/06:00016826!RIV10-MSM-14310___" . "Long range scalar 5J(H1',F) couplings were observed in 5-fluoropyrimidine substituted RNA. We developed a novel S3E-19F-alfa/beta-edited NOESY experiment for quantitation of these long range scalar 5J(H1',F), where the J-couplings can be extracted from inspection of intraresidual (H1',H6) NOE crosspeaks. The 5J(H1',F) couplings can be used to restrict the glycosidic torsion angle which defines the orientation of the base with respect to the ribose sugar moiety. Quantum chemical calculations were exploited to investigate the relation between scalar couplings and conformations around the glycosidic bond in oligonucleotides. The theoretical dependence of the observed 5J(H1',F) couplings on the torsion angle \u00D3 can be described by a generalized Karplus relationship. The corresponding density functional theory (DFT) analysis is outlined." . . "Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA." . . . . "Scalar Coupling Constants; Fluorine; 5-Fluorouridine; 5-Fluorocytidine; HIV-TAR RNA"@en . . "CZ - \u010Cesk\u00E1 republika" . "Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA."@en . "Long range scalar 5J(H1',F) couplings were observed in 5-fluoropyrimidine substituted RNA. We developed a novel S3E-19F-alfa/beta-edited NOESY experiment for quantitation of these long range scalar 5J(H1',F), where the J-couplings can be extracted from inspection of intraresidual (H1',H6) NOE crosspeaks. The 5J(H1',F) couplings can be used to restrict the glycosidic torsion angle which defines the orientation of the base with respect to the ribose sugar moiety. Quantum chemical calculations were exploited to investigate the relation between scalar couplings and conformations around the glycosidic bond in oligonucleotides. The theoretical dependence of the observed 5J(H1',F) couplings on the torsion angle \u00D3 can be described by a generalized Karplus relationship. The corresponding density functional theory (DFT) analysis is outlined."@en . "[BC3607F5AC8B]" . "6"^^ . "Z(MSM0021622413)" .