"RNA kink-turns as molecular elbows: Hydration, cation binding, and large-scale dynamics" . . "14" . "R\u00E1zga, Filip" . . . "RNA kink-turns as molecular elbows: Hydration, cation binding, and large-scale dynamics"@en . . "Zacharias, Martin" . . "The presence of Kink-turns (Kt) at key functional sites in the ribosome (e.g., A-site finger and L7/L12 stalk) suggests that some Kink-turns can confer flexibility on RNA protuberances that regulate the traversal of tRNAs during translocation. Explicit solvent molecular dynamics demonstrates that Kink-turns can act as flexible molecular elbows. Kink-turns are associated with a unique network of long-residency static and dynamical hydration sites that is intimately involved in modulating their conformational dynamics. An implicit solvent conformational search confirms the flexibility of Kink-turns around their X-ray geometries and identifies a second low-energy region with open structures that could correspond to Kink-turn geometries seen in solution experiments. An extended simulation of Kt-42 with the factor binding site (helices 43 and 44) shows that the local Kt-42 elbow-like motion fully propagates beyond the Kink-turn, and that there is no other comparably flexible site in this rRNA region."@en . . . . . "Kink-turn; A-minor motif; RNA flexibility; Molecular Dynamics; Ribosome function"@en . . "Ko\u010Da, Jaroslav" . "4"^^ . "RNA kink-turns as molecular elbows: Hydration, cation binding, and large-scale dynamics"@en . . "Structure" . "[3C4021325433]" . "RNA kink-turns as molecular elbows: Hydration, cation binding, and large-scale dynamics" . . "14310" . . . "R\u00E9blov\u00E1, Kamila" . . . "5"^^ . . . "0969-2126" . . . . . . . . "P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(GD204/03/H016), P(LC512), Z(AV0Z40550506), Z(AV0Z50040507), Z(MSM0021622413)" . "5" . "497738" . "\u0160poner, Ji\u0159\u00ED" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "RIV/00216224:14310/06:00015722!RIV10-MSM-14310___" . . . "10"^^ . "RIV/00216224:14310/06:00015722" . "The presence of Kink-turns (Kt) at key functional sites in the ribosome (e.g., A-site finger and L7/L12 stalk) suggests that some Kink-turns can confer flexibility on RNA protuberances that regulate the traversal of tRNAs during translocation. Explicit solvent molecular dynamics demonstrates that Kink-turns can act as flexible molecular elbows. Kink-turns are associated with a unique network of long-residency static and dynamical hydration sites that is intimately involved in modulating their conformational dynamics. An implicit solvent conformational search confirms the flexibility of Kink-turns around their X-ray geometries and identifies a second low-energy region with open structures that could correspond to Kink-turn geometries seen in solution experiments. An extended simulation of Kt-42 with the factor binding site (helices 43 and 44) shows that the local Kt-42 elbow-like motion fully propagates beyond the Kink-turn, and that there is no other comparably flexible site in this rRNA region." .