"8"^^ . "2006-02-08+01:00"^^ . . "Staphylococcus aureus; bacteriophages; therapy; proteome; MALDI MS"@en . . "Proteom polyvalentn\u00EDho stafylokokov\u00E9ho bakteriof\u00E1ga" . . "8"^^ . "In this study, proteome of the polyvalent staphylococcal bacteriophage is characterized in detail"@en . "[726AEF637BFA]" . "P(GA203/03/0515), Z(MSM0021622415)" . . . "Hernychov\u00E1, Lenka" . . "Proteome of the polyvalent staphylococcal bacteriophage"@en . . . . "Brno" . "Masarykova univerzita v Brn\u011B" . "80-210-3942-6" . "X. Pracovn\u00ED setk\u00E1n\u00ED biochemik\u016F a molekul\u00E1rn\u00EDch biolog\u016F" . "Proteom polyvalentn\u00EDho stafylokokov\u00E9ho bakteriof\u00E1ga"@cs . . . . "Proteome of the polyvalent staphylococcal bacteriophage"@en . "R\u016F\u017Ei\u010Dkov\u00E1, Vladislava" . "Bakteriof\u00E1g 812 je virulentn\u00ED a polyvalentn\u00ED f\u00E1g, z\u00E1stupce \u010Deledi Myoviridae, kter\u00FD se vyzna\u010Duje \u0161irok\u00FDm rozmez\u00EDm hostitele zahrnuj\u00EDc\u00EDm \u0159adu druh\u016F rodu Staphylococcus. Jeho genom je tvo\u0159en line\u00E1rn\u00ED dvou\u0159et\u011Bzcovou DNA o velikosti cca 145 kbp, kter\u00E1 vykazuje vysok\u00FD stupe\u0148 sekven\u010Dn\u00ED homologie s genomy f\u00E1g\u016F K a G1. Polyvalentn\u00ED stafylokokov\u00E9 bakteriof\u00E1gy se v posledn\u00EDch letech staly p\u0159edm\u011Btem z\u00E1jmu s ohledem na jejich mo\u017En\u00E9 praktick\u00E9 vyu\u017Eit\u00ED p\u0159i f\u00E1gov\u00E9 terapii, kter\u00E1 p\u0159edstavuje vhodnou alternativu antibiotikov\u00E9 l\u00E9\u010Dby stafylokokov\u00FDch infekc\u00ED. C\u00EDlem pr\u00E1ce je detailn\u00ED charakterizace proteomu f\u00E1ga 812 a identifikace protein\u016F tvo\u0159\u00EDc\u00EDch f\u00E1gov\u00E9 viriony. F\u00E1g 812 byl pomno\u017Een na kmeni S. aureus SA812, purifikov\u00E1n ultracentrifugac\u00ED v gradientu CsCl a dialyzov\u00E1n proti vod\u011B. DNA uvoln\u011Bn\u00E1 z f\u00E1gov\u00FDch \u010D\u00E1stic byla odstran\u011Bna DN\u00E1zou I. F\u00E1gov\u00E9 proteiny byly denaturov\u00E1ny a k jejich separaci byla pou\u017Eita 1-D a 2-D PAGE. Proteiny byly identifikov\u00E1ny metodou peptidov\u00E9ho mapov\u00E1n\u00ED s vyu\u017Eit\u00EDm MALDI TOF MS a LC MS/MS."@cs . "Preisler, Jan" . . . . "RIV/00216224:14310/06:00015615!RIV10-MSM-14310___" . "Kone\u010Dn\u00E1, Hana" . . "Pant\u016F\u010Dek, Roman" . "Masarykova univerzita" . . "RIV/00216224:14310/06:00015615" . . . "Proteom polyvalentn\u00EDho stafylokokov\u00E9ho bakteriof\u00E1ga"@cs . . "Eyer, Lud\u011Bk" . "Bakteriof\u00E1g 812 je virulentn\u00ED a polyvalentn\u00ED f\u00E1g, z\u00E1stupce \u010Deledi Myoviridae, kter\u00FD se vyzna\u010Duje \u0161irok\u00FDm rozmez\u00EDm hostitele zahrnuj\u00EDc\u00EDm \u0159adu druh\u016F rodu Staphylococcus. Jeho genom je tvo\u0159en line\u00E1rn\u00ED dvou\u0159et\u011Bzcovou DNA o velikosti cca 145 kbp, kter\u00E1 vykazuje vysok\u00FD stupe\u0148 sekven\u010Dn\u00ED homologie s genomy f\u00E1g\u016F K a G1. Polyvalentn\u00ED stafylokokov\u00E9 bakteriof\u00E1gy se v posledn\u00EDch letech staly p\u0159edm\u011Btem z\u00E1jmu s ohledem na jejich mo\u017En\u00E9 praktick\u00E9 vyu\u017Eit\u00ED p\u0159i f\u00E1gov\u00E9 terapii, kter\u00E1 p\u0159edstavuje vhodnou alternativu antibiotikov\u00E9 l\u00E9\u010Dby stafylokokov\u00FDch infekc\u00ED. C\u00EDlem pr\u00E1ce je detailn\u00ED charakterizace proteomu f\u00E1ga 812 a identifikace protein\u016F tvo\u0159\u00EDc\u00EDch f\u00E1gov\u00E9 viriony. F\u00E1g 812 byl pomno\u017Een na kmeni S. aureus SA812, purifikov\u00E1n ultracentrifugac\u00ED v gradientu CsCl a dialyzov\u00E1n proti vod\u011B. DNA uvoln\u011Bn\u00E1 z f\u00E1gov\u00FDch \u010D\u00E1stic byla odstran\u011Bna DN\u00E1zou I. F\u00E1gov\u00E9 proteiny byly denaturov\u00E1ny a k jejich separaci byla pou\u017Eita 1-D a 2-D PAGE. Proteiny byly identifikov\u00E1ny metodou peptidov\u00E9ho mapov\u00E1n\u00ED s vyu\u017Eit\u00EDm MALDI TOF MS a LC MS/MS." . . . "Zdr\u00E1hal, Zbyn\u011Bk" . . . . "Proteom polyvalentn\u00EDho stafylokokov\u00E9ho bakteriof\u00E1ga" . . . "Do\u0161ka\u0159, Ji\u0159\u00ED" . "495698" . "1"^^ . "14310" .