. "Interaction of fibroblast growth factor and C-natriuretic peptide signaling inregulation of chondrocyte proliferation and extracellular matrix homeostasis."@en . "525298" . . "Mekikian, P. B." . "Overexpression of C-natriuretic peptide (CNP) in cartilage partially rescues achondroplasia in the mouse. Here, we studied the interaction of fibroblast growth factor (FGF) and CNP signaling in chondrocytes. CNP antagonized FGF2-induced growth arrest of rat chondrosarcoma (RCS) chondrocytes by inhibition of the Erk mitogen activated protein kinase pathway. This effect of CNP was protein kinase G-dependent and was mimicked by the cGMP analog pCPT-cGMP. FGF2-mediated activation of both MEK and Raf-1 but not Ras or FRS2 was abolished by CNP demonstrating that CNP blocks the Erk pathway at the level of Raf-1. CNP also counteracted the FGF2-mediated degradation of RCS extracellular matrix. CNP partially antagonized FGF2-induced expression, release and activation of several matrix-remodeling molecules including matrix metalloproteinase 2 (MMP2), MMP3, MMP9, MMP10 and MMP13."@en . . "12"^^ . "21" . "Interaction of fibroblast growth factor and C-natriuretic peptide signaling inregulation of chondrocyte proliferation and extracellular matrix homeostasis." . "Z(MSM0021622415)" . "CYCLIC-GMP; ENDOCHONDRAL OSSIFICATION; INTERGLOBULAR DOMAIN; CARTILAGE AGGRECAN; PROTEIN-KINASES"@en . . "7"^^ . "10.1242/jcs.02618" . "Wilcox, W. R." . "RIV/00216224:14310/05:00059335" . "RIV/00216224:14310/05:00059335!RIV13-MSM-14310___" . . "Prats, H." . . . "Fontaine, V." . "1"^^ . . "Interaction of fibroblast growth factor and C-natriuretic peptide signaling inregulation of chondrocyte proliferation and extracellular matrix homeostasis."@en . "Interaction of fibroblast growth factor and C-natriuretic peptide signaling inregulation of chondrocyte proliferation and extracellular matrix homeostasis." . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . "Krej\u010D\u00ED, Pavel" . "Weis, M." . "Journal of Cell Science" . "14310" . . "118" . . . . . "Overexpression of C-natriuretic peptide (CNP) in cartilage partially rescues achondroplasia in the mouse. Here, we studied the interaction of fibroblast growth factor (FGF) and CNP signaling in chondrocytes. CNP antagonized FGF2-induced growth arrest of rat chondrosarcoma (RCS) chondrocytes by inhibition of the Erk mitogen activated protein kinase pathway. This effect of CNP was protein kinase G-dependent and was mimicked by the cGMP analog pCPT-cGMP. FGF2-mediated activation of both MEK and Raf-1 but not Ras or FRS2 was abolished by CNP demonstrating that CNP blocks the Erk pathway at the level of Raf-1. CNP also counteracted the FGF2-mediated degradation of RCS extracellular matrix. CNP partially antagonized FGF2-induced expression, release and activation of several matrix-remodeling molecules including matrix metalloproteinase 2 (MMP2), MMP3, MMP9, MMP10 and MMP13." . "0021-9533" . "[F3B7F352BC27]" . "000233678700019" . "Masri, B." . .