"CZ - \u010Cesk\u00E1 republika" . "Na\u0161e prvn\u00ED zku\u0161enosti s preimplanta\u010Dn\u00ED genetickou diagnostikou"@cs . . "PGD; chromosomal aberrations; FISH; PCR; cystic fibrosis"@en . "Val\u00E1\u0161kov\u00E1, Iveta" . "535162" . "1018-4813" . . . "Our first experience in preimplantation genetic diagnosis."@en . "Pr\u00E1ce se zab\u00FDv\u00E1 prvn\u00EDmi zku\u0161enostmi pracovi\u0161t\u011B OLG FN Brno a Laborato\u0159e molekul\u00E1rn\u00ED cytogenetiky P\u0159F MU s preimplanta\u010Dn\u00ED genetickou diagnostikou p\u0159i vy\u0161et\u0159ov\u00E1n\u00ED po\u010Detn\u00EDch i strukturn\u00EDch chromozomov\u00FDch abnormalit a n\u011Bkter\u00FDch monogenn\u00EDch onemocn\u011Bn\u00ED (cystick\u00E1 fibr\u00F3za)."@cs . "1"^^ . "RIV/00216224:14310/05:00014636!RIV06-MSM-14310___" . . "RIV/00216224:14310/05:00014636" . "13" . "Prevention of the birth of affected children in couples at risk for transmitting a genetic disorder is currently based on population screening and prenatal diagnosis, followed by termination of affected pregnancies. However, this is the most sensitive problem in the control of genetic disease, which is incompatible with life or not tolerated in populations and ethnic groups. Preimplantation genetic diagnosis (PGD) is a principally new approach for the prevention of genetic disorders, which allows the selection of unaffected IVF embryos for establishing pregnancies in couples at risk. PGD may be achieved by testing female gametes (polar body analysis), blastomeres from cleavage stage embryos, or blastocysts. PGD can be applied for monogenic disorders or chromosomal abnormalities, using diagnostic protocols based on the polymerase chain reaction (PCR) or fluorescence in situ hybridisation (FISH), respectively. Our genetic centre at present concentrates on chromosomal abnormalities, while also on genot" . . . . "268" . . . "Na\u0161e prvn\u00ED zku\u0161enosti s preimplanta\u010Dn\u00ED genetickou diagnostikou"@cs . "Sl\u00E1mov\u00E1, Iva" . "Kadlecov\u00E1, Jitka" . "Gaillyov\u00E1, Renata" . "Kugl\u00EDk, Petr" . "Our first experience in preimplantation genetic diagnosis." . . "Our first experience in preimplantation genetic diagnosis." . . "1"^^ . "Suppl. 1" . . "European Journal of Human Genetics" . . . "[5EC8080A94A4]" . . "Our first experience in preimplantation genetic diagnosis."@en . "14310" . "5"^^ . . . "Prevention of the birth of affected children in couples at risk for transmitting a genetic disorder is currently based on population screening and prenatal diagnosis, followed by termination of affected pregnancies. However, this is the most sensitive problem in the control of genetic disease, which is incompatible with life or not tolerated in populations and ethnic groups. Preimplantation genetic diagnosis (PGD) is a principally new approach for the prevention of genetic disorders, which allows the selection of unaffected IVF embryos for establishing pregnancies in couples at risk. PGD may be achieved by testing female gametes (polar body analysis), blastomeres from cleavage stage embryos, or blastocysts. PGD can be applied for monogenic disorders or chromosomal abnormalities, using diagnostic protocols based on the polymerase chain reaction (PCR) or fluorescence in situ hybridisation (FISH), respectively. Our genetic centre at present concentrates on chromosomal abnormalities, while also on genot"@en . "Z(MSM0021622415)" .