. . "Analytical and Bioanalytical Chemistry" . . "542303" . "Z(MSM0021622413)" . "Scheller, Frieder" . "7"^^ . . "3"^^ . "Sensitive detection of organophosphates in river water by means of a piezoelectric biosensor"@en . "14310" . . "P\u0159ibyl, Jan" . . . "Sensitive detection of organophosphates in river water by means of a piezoelectric biosensor"@en . "Piezoelectric sensor; Quartz crystal microbalance; Acetylcholinesterase; Inhibitor"@en . "[1A8CFB36274F]" . . . "Sensitive detection of organophosphates in river water by means of a piezoelectric biosensor" . "Makower, Alexander" . . "A highly sensitive piezoelectric biosensor has been developed for detection of cholinesterase inhibitors.The inhibitor benzoylecgonine-1,8-diamino-3,4-dioxaoctane(BZE-DADOO) was immobilized on a monolayer of 11-mercaptomonoundecanoic acid (MUA) selfassembled on the gold surface of the sensor. The binding of high-molecular-weight cholinesterase to the immobilized cocaine derivative was monitored with a mass sensitive piezoelectric quartz crystal (quartz crystal nanobalance; QCN). In the presence of an inhibiting substance in the sample, the binding of cholinesterase to the immobilized inhibitor was reduced. The decrease of the rate of mass change was proportional to the concentration of free inhibitor in the sample. This way the affinity sensor followed anti-cholinesterase toxicity and the enzyme activity of ChE was not addressed. An assay for detection of organophosphates (OP) was optimized."@en . "5"^^ . "Hal\u00E1mek, Jan" . "RIV/00216224:14310/05:00014127" . "A highly sensitive piezoelectric biosensor has been developed for detection of cholinesterase inhibitors.The inhibitor benzoylecgonine-1,8-diamino-3,4-dioxaoctane(BZE-DADOO) was immobilized on a monolayer of 11-mercaptomonoundecanoic acid (MUA) selfassembled on the gold surface of the sensor. The binding of high-molecular-weight cholinesterase to the immobilized cocaine derivative was monitored with a mass sensitive piezoelectric quartz crystal (quartz crystal nanobalance; QCN). In the presence of an inhibiting substance in the sample, the binding of cholinesterase to the immobilized inhibitor was reduced. The decrease of the rate of mass change was proportional to the concentration of free inhibitor in the sample. This way the affinity sensor followed anti-cholinesterase toxicity and the enzyme activity of ChE was not addressed. An assay for detection of organophosphates (OP) was optimized." . "1618-2642" . "Skl\u00E1dal, Petr" . . "CZ - \u010Cesk\u00E1 republika" . "5" . . . . . . "RIV/00216224:14310/05:00014127!RIV10-MSM-14310___" . "Sensitive detection of organophosphates in river water by means of a piezoelectric biosensor" . . "382" . .