. . "Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts"@en . "Sou\u010Dek, Karel" . "Horv\u00E1th, Viktor" . "513424" . "Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts" . "RIV/00216224:14310/05:00012715!RIV06-MSM-14310___" . "Monoblasty transformovan\u00E9 onkogenem v-myb a ovlivn\u011Bn\u00E9 kamptotecinem odum\u00EDraj\u00ED autofagi\u00ED"@cs . "Malignitransfrmaci \u010Dasto doprov\u00E1z\u00ED po\u0161kozen\u00ED drah programovan\u00E9 bun\u011B\u010Dn\u00E9 smri (PCD). V t\u00E9to pr\u00E1ci jsme analyzovali PCD monoblast\u016F transformovan\u00FDch v-myb a promonocyt\u016F U937, kter\u00E1 byla indukov\u00E1na oxidem adrzenit\u00FDm, cykloheximidem a kamptotecinem. P\u0159\u00EDtomnost funk\u010Dn\u00EDho proteinu v-Myb predeterminovala bu\u0148ky BM2 vystaven\u00E1 \u010Dinidl\u016Fm po\u0161kozuj\u00EDc\u00EDm DNA k PCD autofagi\u00ED. Nep\u0159\u00EDtomnost funk\u010Dn\u00EDho proteinu v-Myb umo\u017Enila aktivaci dr\u00E1hy PCD doprov\u00E1zen\u00E9 depolarizac\u00ED mitochondri\u00E1ln\u00ED membr\u00E1ny a vedouc\u00ED k nekr\u00F3ze. Fakt, \u017Ee antiapoptotick\u00E1 funkce onkoproteinu v-Myb m\u016F\u017Ee b\u00FDt p\u0159ekon\u00E1na indukc\u00ED alternativn\u00ED dr\u00E1hy PCD nazna\u010Duje, \u017Ee pochopen\u00ED molekul\u00E1rn\u00EDchmechanism\u016F autofagie by mohlo p\u0159isp\u011Bt ke zlep\u0161en\u00ED terapie n\u00E1dorov\u00FDch bun\u011Bk se sn\u00ED\u017Eenou schopnost\u00ED apopt\u00F3zy."@cs . "14310" . "A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis."@en . "RIV/00216224:14310/05:00012715" . . "Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts"@en . "\u0160marda, Jan" . "A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis." . "CZ - \u010Cesk\u00E1 republika" . "v-Myb; apoptosis; autophagy; camptohecin"@en . . . . "3/2005" . "Ondrou\u0161kov\u00E1, Eva" . . "Monoblasty transformovan\u00E9 onkogenem v-myb a ovlivn\u011Bn\u00E9 kamptotecinem odum\u00EDraj\u00ED autofagi\u00ED"@cs . "[DA37B8B59D9F]" . . . "Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts" . "2"^^ . "Journal of Applied Biomedicine" . "S49-S50" . "Suppl. 1" . . . . . . . "1214-0287" . . . "P(GA301/03/1055), Z(MSM0021622415)" . "4"^^ . . "4"^^ . . . .