"RIV/00216224:14310/04:00019957!RIV08-GA0-14310___" . "Humic acids; AhR"@en . "Bl\u00E1ha, Lud\u011Bk" . "Praha" . . "Huminov\u00E9 kyseliny jako mo\u017En\u00E9 aktiv\u00E1tory AhR"@cs . . . . "Humic Acids as Potential Activators of the Aryl Hydrocarbon Receptor" . "[99C27681BC3E]" . "Giesy, John Paul" . . "Humic Acids as Potential Activators of the Aryl Hydrocarbon Receptor"@en . . "P(GA525/03/0367)" . "Hilscherov\u00E1, Kl\u00E1ra" . . . "22-23" . "USA" . . . "Pure humic substances (HS) are generally regarded to be inert in ecosystems. Ecotoxicological function of HS in environment is often discussed in connection with the sorption of heavy metals and various organic xenobiotics, consequently decreasing their bioavailability and toxicity. But there were published some studies that HS can probably induce direct adverse effect on human health. That is discussed with connection to endemic appearance of Black foot disease and Kashin-Becks disease in some areas in China and Taiwan. Some experiments showed that oxidative stress caused by HS leads to damage of erythrocytes and fragmentation of DNA with subsequent apoptosis in chondrocytes. HS are the major components of the mixture of materials that comprise soil organic matter, and represent the major components of dissolved organic matter in waters. Chemical constitution of HS depends on the source of degraded organic materials, consequently HS comprise a variety of molecular structures and it is not possible to" . . "2004-01-01+01:00"^^ . "Humic Acids as Potential Activators of the Aryl Hydrocarbon Receptor" . . "Texas A&M University" . "First Biennial Central & Eastern European Environmental Health Conference" . . "Bittner, Michal" . "Pure humic substances (HS) are generally regarded to be inert in ecosystems. Ecotoxicological function of HS in environment is often discussed in connection with the sorption of heavy metals and various organic xenobiotics, consequently decreasing their bioavailability and toxicity. But there were published some studies that HS can probably induce direct adverse effect on human health. That is discussed with connection to endemic appearance of Black foot disease and Kashin-Becks disease in some areas in China and Taiwan. Some experiments showed that oxidative stress caused by HS leads to damage of erythrocytes and fragmentation of DNA with subsequent apoptosis in chondrocytes. HS are the major components of the mixture of materials that comprise soil organic matter, and represent the major components of dissolved organic matter in waters. Chemical constitution of HS depends on the source of degraded organic materials, consequently HS comprise a variety of molecular structures and it is not possible to"@en . "5"^^ . . "Humic Acids as Potential Activators of the Aryl Hydrocarbon Receptor"@en . . "Huminov\u00E9 kyseliny jako mo\u017En\u00E9 aktiv\u00E1tory AhR"@cs . "14310" . "Jano\u0161ek, Jaroslav" . "6"^^ . . "P\u0159elo\u017Ete si anglick\u00FD."@cs . . "566861" . "2"^^ . "Holoubek, Ivan" . . "RIV/00216224:14310/04:00019957" . .