. . "Gen pro COMT ovliv\u0148uje dispozice k alkoholizmu u mu\u017E\u016F \u010Cesk\u00E9 republiky" . "14310" . "Gen pro COMT ovliv\u0148uje dispozice k alkoholizmu u mu\u017E\u016F \u010Cesk\u00E9 republiky"@cs . . . . "339-342" . . . "100" . "COMT gene influences dispositions to the alcoholism in men of the Czech Republic"@en . "Gen pro COMT ovliv\u0148uje dispozice k alkoholizmu u mu\u017E\u016F \u010Cesk\u00E9 republiky"@cs . . "Last 15 years, genetic aspects of dispositions to alcohol dependence in a relationship with dopamine system are frequently studied. Catechol-o-metyltransferase (COMT) is enzyme involved in the metabolism of dopamine, serotonin and noradrenalin. Val158Met polymorphism of COMT gene was previously associated with enzyme activity, with an alcoholism etc. In our association study we studied a relationship between Val158Met polymorphism of COMT gene and alcoholism on the group of 799 subjects. We found a statistically significant difference in allelic and genotype frequencies between male alcoholics and male controls. Our results proved the relationship between Val158Met polymorphism of COMT gene and alcoholism in male part of population of the Czech Republic."@en . "RIV/00216224:14310/04:00012174" . "6" . . "P(NR8137)" . "3"^^ . "Genetick\u00E9 aspekty dispozic k z\u00E1vislosti na alkoholu jsou v posledn\u00EDch 15 letech \u0161iroce zkoum\u00E1ny v souvislosti s dopaminov\u00FDm syst\u00E9mem. Katechol-o-metyltransfer\u00E1za (COMT) je enzym, kter\u00FD se mimo jin\u00E9 pod\u00EDl\u00ED na metabolizmu dopaminu, serotoninu a noradrenalinu. Val158Met polymorfizmus genu pro COMT byl ji\u017E d\u0159\u00EDve asociov\u00E1n s enzymovou aktivitou tohoto enzymu a krom jin\u00FDch psychick\u00FDch poruch tak\u00E9 s alkoholismem. V na\u0161\u00ED asocia\u010Dn\u00ED studii jsme zkoumali vztah mezi Val158Met polymorfizmem genu pro COMT a alkoholizmem na souboru 799 osob a objevili jsme statisticky signifikantn\u00ED rozd\u00EDl v alelick\u00FDch i genotypov\u00FDch frekvenc\u00EDch mezi mu\u017Ei alkoholiky a mu\u017Ei z kontroln\u00EDho souboru. Na\u0161e pr\u00E1ce potvrdila vztah mezi Val158Met polymorfizmem genu pro COMT a alkoholizmem v mu\u017Esk\u00E9 \u010D\u00E1sti populace \u010Cesk\u00E9 republiky."@cs . . "Pitelov\u00E1, Ren\u00E1ta" . . "565219" . "alcoholism, COMT, association study, polymorphism, PCR"@en . . . . . . "3"^^ . . . . "RIV/00216224:14310/04:00012174!RIV/2005/MZ0/143105/N" . "COMT gene influences dispositions to the alcoholism in men of the Czech Republic"@en . "Zvolsk\u00FD, Petr" . "CZ - \u010Cesk\u00E1 republika" . "\u010Cesk\u00E1 a slovensk\u00E1 psychiatrie" . "Genetick\u00E9 aspekty dispozic k z\u00E1vislosti na alkoholu jsou v posledn\u00EDch 15 letech \u0161iroce zkoum\u00E1ny v souvislosti s dopaminov\u00FDm syst\u00E9mem. Katechol-o-metyltransfer\u00E1za (COMT) je enzym, kter\u00FD se mimo jin\u00E9 pod\u00EDl\u00ED na metabolizmu dopaminu, serotoninu a noradrenalinu. Val158Met polymorfizmus genu pro COMT byl ji\u017E d\u0159\u00EDve asociov\u00E1n s enzymovou aktivitou tohoto enzymu a krom jin\u00FDch psychick\u00FDch poruch tak\u00E9 s alkoholismem. V na\u0161\u00ED asocia\u010Dn\u00ED studii jsme zkoumali vztah mezi Val158Met polymorfizmem genu pro COMT a alkoholizmem na souboru 799 osob a objevili jsme statisticky signifikantn\u00ED rozd\u00EDl v alelick\u00FDch i genotypov\u00FDch frekvenc\u00EDch mezi mu\u017Ei alkoholiky a mu\u017Ei z kontroln\u00EDho souboru. Na\u0161e pr\u00E1ce potvrdila vztah mezi Val158Met polymorfizmem genu pro COMT a alkoholizmem v mu\u017Esk\u00E9 \u010D\u00E1sti populace \u010Cesk\u00E9 republiky." . "\u0160er\u00FD, Omar" . "Gen pro COMT ovliv\u0148uje dispozice k alkoholizmu u mu\u017E\u016F \u010Cesk\u00E9 republiky" . "1212-0383" . "[7BECAA07B66F]" . "4"^^ .