. "Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns"@en . "RIV/00216224:14310/04:00009958!RIV/2005/MSM/143105/N" . "Krystalografick\u00E1 spole\u010Dnost" . "Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns" . . . . . "Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns" . "R\u00E9blov\u00E1, Kamila" . . . "Ko\u010Da, Jaroslav" . "14310" . "Materials Structure in Chemistry, Biology, Physics and Technology" . . "Leontis, Neocles B." . "\u0160poner, Ji\u0159\u00ED" . . "Molecular dynamics, RNA flexibility, non-Watson-Crick basepair, modular building, long-residency hydration"@en . "1211-5894" . "Academic and University Center, Nov\u00E9 Hrady" . "RIV/00216224:14310/04:00009958" . "Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns"@en . . . "Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov"@cs . . . "6"^^ . . "5"^^ . "Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov"@cs . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA"@cs . "\u0160pa\u010Dkov\u00E1, Nad\u011B\u017Eda" . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA"@en . . "Praha" . "561485" . . "P(LN00A016)" . . "2004-03-11+01:00"^^ . "R\u00E1zga, Filip" . "1"^^ . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA" . . . "28" . "[686139F44B22]" . . . .