"Structure and Dynamics of RNA K-turn Motifs" . "Praha" . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula"@en . "RIV/00216224:14310/03:00009894!RIV08-MSM-14310___" . . . "Structure and Dynamics of RNA K-turn Motifs"@en . . . "21-21" . "Praha" . "2003-09-25+02:00"^^ . "RIV/00216224:14310/03:00009894" . "Praha" . "14310" . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula"@cs . "Leontis, Neocles B." . . "RNA klub" . "R\u00E9blov\u00E1, Kamila" . "5"^^ . . "1"^^ . . "R\u00E1zga, Filip" . "Ko\u010Da, Jaroslav" . "\u0160poner, Ji\u0159\u00ED" . . . "Structure and Dynamics of RNA K-turn Motifs"@en . "Struktura a dynamika RNA KInk-turn motivov"@cs . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula" . "6"^^ . . . "Structure and Dynamics of RNA K-turn Motifs" . "\u0160pa\u010Dkov\u00E1, Nad\u011B\u017Eda" . . "Molecular Dynamics; non-Watson-Crick basepairs; RNA flexibility"@en . . "Struktura a dynamika RNA KInk-turn motivov"@cs . . "[8C6357CD93BF]" . "P(LN00A016)" . . . . . . "629231" . .