. "\u0160poner, Ji\u0159\u00ED" . "P(LN00A016)" . "RIV/00216224:14310/03:00009270" . "Workshop on Modeling Interactions in Biomolecules : Programme and Book of Abstract" . . "Structure And Dynamics Of RNA K-Turn Motifs" . . "Structure And Dynamics Of RNA K-Turn Motifs" . . "Molecular dynamics; RNA flexibility; non-Watson-Crick basepair"@en . . "Nove Hrady" . "\u0160pa\u010Dkov\u00E1, Nad\u011B\u017Eda" . . "RIV/00216224:14310/03:00009270!RIV08-MSM-14310___" . "Structure And Dynamics Of RNA K-Turn Motifs"@en . . . "Structure And Dynamics Of RNA K-Turn Motifs"@en . "Praha" . . "Praha" . . "2003-09-15+02:00"^^ . "629232" . . . . "Structure And Dynamics Of RNA K-Turn Motifs"@cs . . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38, and K-turn 42, and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility of the K-turns,indicating that these motifs function as very flexible internal loops linking rigid helix stems and capable regulating s" . "[77E13B20F336]" . . "14310" . "1"^^ . . . "Leontis, Neocles B." . . . "41-41" . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38, and K-turn 42, and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility of the K-turns,indicating that these motifs function as very flexible internal loops linking rigid helix stems and capable regulating s"@en . "6"^^ . . "R\u00E9blov\u00E1, Kamila" . "5"^^ . "Structure And Dynamics Of RNA K-Turn Motifs"@cs . "Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38, and K-turn 42, and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility of the K-turns,indicating that these motifs function as very flexible internal loops linking rigid helix stems and capable regulating s"@cs . "Ko\u010Da, Jaroslav" . "R\u00E1zga, Filip" .