"Masarykova univerzita v Brn\u011B" . "Studium n\u00E1dorov\u011B supresivn\u00EDch \u00FA\u010Dink\u016F proteinu p53 na leukemick\u00E9 monoblasty BM2" . . "1"^^ . "We created a transgenic variant of the BM2 cell line of v-myb-transformed monoblasts inducibly expressing human p53. Transcription activation function of p53 as well as its intracellular concentration is kept low under regular conditions. DNA damage or another stressing attack cause increase of p53 stability and activation of its capability to transactivate target genes. The level of p53 decreases in 24 hours to its original amount during 24 hours in BM2p53 cell in spite of continuous presence of inducer. The temporal increase of p53 level did not affect growth and/or apoptosis of BM2p53 cells. However, rosocovitine- or adriamycine-treatment increased stability of the p53 protein causing lower viability of BM2p53 cells. At the same time molecular weight of p53 increased."@en . . "Studium n\u00E1dorov\u011B supresivn\u00EDch \u00FA\u010Dink\u016F proteinu p53 na leukemick\u00E9 monoblasty BM2"@cs . . "2002-01-01+01:00"^^ . . "Navr\u00E1tilov\u00E1, Jarmila" . "RIV/00216224:14310/02:00006923!RIV08-MSM-14310___" . . "4"^^ . . "665640" . "Z(MSM 143100008)" . "\u0160marda, Jan" . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . "VI. Pracovn\u00ED setk\u00E1n\u00ED biochemik\u016F a molekul\u00E1rn\u00EDch biolog\u016F" . "Brno" . "27" . "4"^^ . . "P\u0159i hled\u00E1n\u00ED podm\u00EDnek suprese transforma\u010Dn\u00ED funkce onkoproteinu v-Myb jsme vytvo\u0159ili transgenn\u00ED variantu linie BM2, kter\u00E1 inducibiln\u011B exprimuje gen k\u00F3duj\u00EDc\u00ED lidsk\u00FD protein p53. Za standardn\u00EDch podm\u00EDnek je funkce p53 jako aktiv\u00E1toru transkripce potla\u010Dena a jeho koncentrace v bu\u0148ce se udr\u017Euje na velmi n\u00EDzk\u00E9 \u00FArovni. Po\u0161kozen\u00ED DNA a jin\u00E9 stresuj\u00EDc\u00ED podn\u011Bty vedou ke stabilizaci p53 a aktivaci jeho transaktiva\u010Dn\u00ED funkce. Hladina p53 v bu\u0148k\u00E1ch BM2p53 v rozmez\u00ED 24 hodin kles\u00E1 na v\u00FDchoz\u00ED \u00FArove\u0148 a to p\u0159es st\u00E1lou p\u0159\u00EDtomnost induktoru. P\u0159echodn\u00E9 zv\u00FD\u0161en\u00ED mno\u017Estv\u00ED proteinu p53 nem\u011Blo vliv na r\u016Fstov\u00E9 vlastnosti a apopt\u00F3zu bun\u011Bk BM2p53. Stabilizace proteinu p53 p\u016Fsoben\u00EDm roskovitinu a adriamycinu je prov\u00E1zena zv\u00FD\u0161en\u00EDm molekulov\u00E9 hmotnosti p53 a vede k sn\u00ED\u017Een\u00ED viability bun\u011Bk BM2p53." . "The study of tumor suppressive effects of p53 protein on leukemic monoblasts BM2"@en . "P\u0159i hled\u00E1n\u00ED podm\u00EDnek suprese transforma\u010Dn\u00ED funkce onkoproteinu v-Myb jsme vytvo\u0159ili transgenn\u00ED variantu linie BM2, kter\u00E1 inducibiln\u011B exprimuje gen k\u00F3duj\u00EDc\u00ED lidsk\u00FD protein p53. Za standardn\u00EDch podm\u00EDnek je funkce p53 jako aktiv\u00E1toru transkripce potla\u010Dena a jeho koncentrace v bu\u0148ce se udr\u017Euje na velmi n\u00EDzk\u00E9 \u00FArovni. Po\u0161kozen\u00ED DNA a jin\u00E9 stresuj\u00EDc\u00ED podn\u011Bty vedou ke stabilizaci p53 a aktivaci jeho transaktiva\u010Dn\u00ED funkce. Hladina p53 v bu\u0148k\u00E1ch BM2p53 v rozmez\u00ED 24 hodin kles\u00E1 na v\u00FDchoz\u00ED \u00FArove\u0148 a to p\u0159es st\u00E1lou p\u0159\u00EDtomnost induktoru. P\u0159echodn\u00E9 zv\u00FD\u0161en\u00ED mno\u017Estv\u00ED proteinu p53 nem\u011Blo vliv na r\u016Fstov\u00E9 vlastnosti a apopt\u00F3zu bun\u011Bk BM2p53. Stabilizace proteinu p53 p\u016Fsoben\u00EDm roskovitinu a adriamycinu je prov\u00E1zena zv\u00FD\u0161en\u00EDm molekulov\u00E9 hmotnosti p53 a vede k sn\u00ED\u017Een\u00ED viability bun\u011Bk BM2p53."@cs . . . . "7.2. 2002, Brno" . . "[DDD25F23AA0D]" . . "Studium n\u00E1dorov\u011B supresivn\u00EDch \u00FA\u010Dink\u016F proteinu p53 na leukemick\u00E9 monoblasty BM2" . . . . "\u0160ev\u010D\u00EDkov\u00E1, Sabina" . . "14310" . . "Studium n\u00E1dorov\u011B supresivn\u00EDch \u00FA\u010Dink\u016F proteinu p53 na leukemick\u00E9 monoblasty BM2"@cs . . "RIV/00216224:14310/02:00006923" . "p53; BM2; monoblast; roscovitine"@en . . "The study of tumor suppressive effects of p53 protein on leukemic monoblasts BM2"@en . "80-210-2777-0" . .