. "Hofr, Ctirad" . . . "Brabec, Viktor" . . "14"^^ . "14310" . . "DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands" . "DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands" . . "RIV/00216224:14310/00:00003309!RIV/2002/GA0/143102/N" . "Natile, Giovanni" . "DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands"@en . "Biophysical Journal" . . "DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands"@en . "CZ - \u010Cesk\u00E1 republika" . . "Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously."@en . "0006-3465" . "DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands"@en . . . "P(GA305/99/0695)" . "78" . . "2"^^ . "RIV/00216224:14310/00:00003309" . . "Malina, Jaroslav" . "2008" . "[F76FDB95D6F1]" . "0"^^ . "Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously." . "709007" . "0"^^ . . "2000" . . "5"^^ . "Maresca, Lucciana" .