"Pou\u017Eit\u00ED interferonu u chronick\u00E9 imunn\u00ED trombocytopenick\u00E9 purpury v d\u011Btsk\u00E9m v\u011Bku"@cs . . "[388E1F762BA6]" . "604" . . "14110" . . "Using interferon near chronical ITP in children's age"@en . . . "Pou\u017Eit\u00ED interferonu u chronick\u00E9 imunn\u00ED trombocytopenick\u00E9 purpury v d\u011Btsk\u00E9m v\u011Bku"@cs . "\u010Cesko-slovensk\u00E1 pediatrie" . . "Pou\u017Eit\u00ED interferonu u chronick\u00E9 imunn\u00ED trombocytopenick\u00E9 purpury v d\u011Btsk\u00E9m v\u011Bku" . "Hrstkov\u00E1, Hana" . . "Bajer, Milan" . "Pou\u017Eit\u00ED interferonu u chronick\u00E9 imunn\u00ED trombocytopenick\u00E9 purpury v d\u011Btsk\u00E9m v\u011Bku" . "CZ - \u010Cesk\u00E1 republika" . . "P(IZ3710)" . "Using interferon near chronical ITP in children's age"@en . "Chronic immune thrombocytopenic purpura (ITP) is relatively rare in children and affects some 10% children witch contract ITP. Its treatment is very difficult. The authors used for treatment of chronic ITP in a group of 16 children(8 boys and 8 girls) aged 4-18 years and 6.8 months interferon alpha 2a - 3 million u./1 m2 three times per week in 12-15 doses. The therapeutic results are relatively good and the therapeutic response is very good, i.e. an increase of the number of thrombocytes above 100 x 10/2/l after completed treatment was recorded in six children. Six months after terminated interferon treatment a very good therapeutic response was found in three children and a good therapeutic response (thrombocyte level 50.0 x 10/9/l - 100.0 x 10/9/l) in six children. From the therapeutic results it is apparent that possibilities in chronic ITP in children and frequently a rise of thrombocyte numbers is found. Side-effects of treatment were minimal. However, the rise of the thrombocyte level was not a"@en . . "RIV/00216224:14110/98:00003838!RIV/2002/MZ0/141102/N" . "Using interferon near chronical ITP in children's age"@en . . "0"^^ . "Chronick\u00E1 imunn\u00ED trombocytopenick\u00E1 purpura (ITP) je u d\u011Bt\u00ED pom\u011Brn\u011B vz\u00E1cn\u00E1 a postihuje asi 10% d\u011Bt\u00ED, kter\u00E9 onemocn\u00ED ITP. Jej\u00ED l\u00E9\u010Dba je ale velmi sv\u00EDzeln\u00E1. Auto\u0159i pou\u017Eili k terapii chronick\u00E9 ITP u souboru 16 d\u011Bt\u00ED (8 chlapc\u016F a 8 d\u00EDve) ve v\u011Bku 4 - 18 let, pr\u016Fm\u011Brn\u00FD v\u011Bk 10 rok\u016F a 6,8 m\u011Bs\u00EDc\u016F, interferon alfa 2a v d\u00E1vce 3 miliony j/1 m na 2 3x t\u00FDdn\u011B ve 12-15 d\u00E1vk\u00E1ch. L\u00E9\u010Debn\u00E9 v\u00FDsledky jsou pom\u011Brn\u011B dobr\u00E9 a velmi dobr\u00E1 terapeutick\u00E1 odpov\u011B\u010F, tedy vzestup po\u010Dtu trombocyt\u016F nad 100 x 10 na 9/l po skon\u010Den\u00E9 terapii, byla zji\u0161t\u011Bna u 6 d\u011Bt\u00ED. Za p\u016Fl roku po skon\u010Den\u00E9 l\u00E9\u010Db\u011B interferonem byla velmi dobr\u00E1 terapeutick\u00E1 odpov\u011B\u010F nalezena u 3 d\u011Bt\u00ED a dobr\u00E1 terapeutick\u00E1 odpov\u011B\u010F (hodnota trombocyt\u016F 50,0 x 10 na 9/l -100,0 x 10 na 9/l) u d\u011Bt\u00ED. Z l\u00E9\u010Debn\u00FDch v\u00FDsledk\u016F je z\u0159ejm\u00E9, \u017Ee terapie interferonem p\u0159edstavuje jednu z l\u00E9\u010Debn\u00FDch mo\u017Enost\u00ED u chronick\u00E9 ITP u d\u011Bt\u00ED a \u010Dasto doch\u00E1z\u00ED ke zv\u00FD\u0161en\u00ED hodnot trombocyt\u016F. Vedlej\u0161\u00ED \u00FA\u010Dinky l\u00E9\u010Dby byly minim\u00E1ln\u00ED. Zv\u00FD\u0161en\u00ED po\u010Dtu trombocyt\u016F ale neb\u00FDv\u00E1 v\u017Edy trval\u00E9." . "10" . "0"^^ . "2"^^ . "779446" . "0069-2328" . . . . "53" . "5"^^ . "RIV/00216224:14110/98:00003838" . . "2"^^ .