"Min\u00E1\u0159, Lubo\u0161" . "4" . "diagnosis; cervical cancer; endometrial cancer; ovarian cancer; blood; microRNA; urine; plasma; serum"@en . "Praktick\u00E1 gynekologie" . . "Cirkuluj\u00EDc\u00ED a extracelul\u00E1rn\u00ED mikroRNA jako nov\u00E9 potenci\u00E1ln\u00ED diagnostick\u00E9 markery pro gynekologick\u00E9 malignity" . . "CZ - \u010Cesk\u00E1 republika" . . "Jand\u00E1kov\u00E1, Eva" . . "Z\u00E1vesk\u00FD, Lud\u011Bk" . "Cirkuluj\u00EDc\u00ED a extracelul\u00E1rn\u00ED mikroRNA jako nov\u00E9 potenci\u00E1ln\u00ED diagnostick\u00E9 markery pro gynekologick\u00E9 malignity"@cs . . "Mal\u00E9 regula\u010Dn\u00ED molekuly, tzv. mikroRNA, se pod\u00EDlej\u00ED na regulaci v\u0161ech z\u00E1kladn\u00EDch \u017Eivotn\u00EDch proces\u016F v bu\u0148k\u00E1ch. Jsou regul\u00E1tory exprese gen\u016F na posttranskrip\u010Dn\u00ED \u00FArovni. Ovliv\u0148uj\u00ED tuto expresi vazbou na c\u00EDlov\u00E9 mRNA, kter\u00E1 vede k blokaci translace a \u0161t\u011Bpen\u00ED mRNA. Nejnov\u011Bj\u0161\u00ED v\u00FDzkumy uk\u00E1zaly, \u017Ee jejich v\u00FDskyt nen\u00ED omezen jen na bu\u0148ky, ale mikroRNA se vyskytuj\u00ED tak\u00E9 v t\u011Bln\u00EDch tekutin\u00E1ch. Vzhledem k tomu, \u017Ee diferenci\u00E1ln\u00ED exprese ur\u010Dit\u00FDch mikroRNA je \u010Dasto asociovan\u00E1 s mnoha patologick\u00FDmi procesy, detekce deregulovan\u00FDch mikroRNA v diagnosticky relevantn\u00EDch vzorc\u00EDch (nap\u0159. krvi, plazm\u011B/s\u00E9ru, mo\u010Di) se m\u016F\u017Ee st\u00E1t z\u00E1kladem nov\u00FDch diagnostick\u00FDch postup\u016F. U gynekologick\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED je nalezen\u00ED nov\u00FDch diagnostick\u00FDch biomarker\u016F d\u016Fle\u017Eit\u00FDm c\u00EDlem sou\u010Dasn\u00FDch v\u00FDzkum\u016F. V tomto \u010Dl\u00E1nku naleznete p\u0159ehled cirkuluj\u00EDc\u00EDch a extracelul\u00E1rn\u00EDch mikroRNA, kter\u00E9 byly nejnov\u011Bji nalezeny deregulov\u00E1ny u karcinomu ovaria, endometria a cervixu, p\u0159edev\u0161\u00EDm ve vzorc\u00EDch krve, s\u00E9ra/plazmy a mo\u010Di." . "Circulating and extracellular microRNAs as new diagnostic biomarkers for gynecological cancers"@en . . . . "[34157AAB24D8]" . . . . "Langmeierov\u00E1, Lucie" . "Turyna, Radovan" . "6"^^ . . . "14110" . . "Weinberger, V\u00EDt" . . . "RIV/00216224:14110/14:00078490" . "Circulating and extracellular microRNAs as new diagnostic biomarkers for gynecological cancers"@en . "Cirkuluj\u00EDc\u00ED a extracelul\u00E1rn\u00ED mikroRNA jako nov\u00E9 potenci\u00E1ln\u00ED diagnostick\u00E9 markery pro gynekologick\u00E9 malignity" . "1211-6645" . "6"^^ . . . . . "RIV/00216224:14110/14:00078490!RIV15-MSM-14110___" . "Cirkuluj\u00EDc\u00ED a extracelul\u00E1rn\u00ED mikroRNA jako nov\u00E9 potenci\u00E1ln\u00ED diagnostick\u00E9 markery pro gynekologick\u00E9 malignity"@cs . "Mal\u00E9 regula\u010Dn\u00ED molekuly, tzv. mikroRNA, se pod\u00EDlej\u00ED na regulaci v\u0161ech z\u00E1kladn\u00EDch \u017Eivotn\u00EDch proces\u016F v bu\u0148k\u00E1ch. Jsou regul\u00E1tory exprese gen\u016F na posttranskrip\u010Dn\u00ED \u00FArovni. Ovliv\u0148uj\u00ED tuto expresi vazbou na c\u00EDlov\u00E9 mRNA, kter\u00E1 vede k blokaci translace a \u0161t\u011Bpen\u00ED mRNA. Nejnov\u011Bj\u0161\u00ED v\u00FDzkumy uk\u00E1zaly, \u017Ee jejich v\u00FDskyt nen\u00ED omezen jen na bu\u0148ky, ale mikroRNA se vyskytuj\u00ED tak\u00E9 v t\u011Bln\u00EDch tekutin\u00E1ch. Vzhledem k tomu, \u017Ee diferenci\u00E1ln\u00ED exprese ur\u010Dit\u00FDch mikroRNA je \u010Dasto asociovan\u00E1 s mnoha patologick\u00FDmi procesy, detekce deregulovan\u00FDch mikroRNA v diagnosticky relevantn\u00EDch vzorc\u00EDch (nap\u0159. krvi, plazm\u011B/s\u00E9ru, mo\u010Di) se m\u016F\u017Ee st\u00E1t z\u00E1kladem nov\u00FDch diagnostick\u00FDch postup\u016F. U gynekologick\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED je nalezen\u00ED nov\u00FDch diagnostick\u00FDch biomarker\u016F d\u016Fle\u017Eit\u00FDm c\u00EDlem sou\u010Dasn\u00FDch v\u00FDzkum\u016F. V tomto \u010Dl\u00E1nku naleznete p\u0159ehled cirkuluj\u00EDc\u00EDch a extracelul\u00E1rn\u00EDch mikroRNA, kter\u00E9 byly nejnov\u011Bji nalezeny deregulov\u00E1ny u karcinomu ovaria, endometria a cervixu, p\u0159edev\u0161\u00EDm ve vzorc\u00EDch krve, s\u00E9ra/plazmy a mo\u010Di."@cs . "Small, non-coding molecules of RNA, microRNAs, have been shown to participate in regulation of key biological processes in the cells. They regulate the expression at post-transcriptional level by binding to target mRNA, resulting in mRNA degradation or translation inhibition. The most recent investigations revealed that microRNAs may occur not only in the cells, but also in many body fluids. Differential expression of particular microRNAs is often associated with many pathological states. Therefore, the detection of deregulated microRNAs in diagnostically relevant samples such as blood, plasma/serum, or urine may become the basis for the establishment of novel diagnostic procedures. Finding alternative diagnostic biomarkers for gynecological cancers is the goal of many recent investigations."@en . . "18" . "7342" . "I" . . "3"^^ .