. . "14110" . "3"^^ . . "1802-2960" . "B\u00E9rcov\u00E9 ulcerace ven\u00F3zn\u00ED etiologie jsou nejt\u011B\u017E\u0161\u00EDm stadiem chronick\u00E9ho \u017Eiln\u00EDho onemocn\u011Bn\u00ED a p\u0159edstavuj\u00ED z\u00E1va\u017En\u00FD zdravotn\u00ED probl\u00E9m. V\u00FDrazn\u011B sni\u017Euj\u00ED kvalitu \u017Eivota pacient\u016F, zejm\u00E9na kv\u016Fli bolesti, sn\u00ED\u017Een\u00E9 mobilit\u011B a poruch\u00E1m sp\u00E1nku. D\u016Fsledkem je ovlivn\u011Bn\u00ED denn\u00EDch aktivit, zejm\u00E9na z\u00E1jmov\u00FDch \u010Dinnost\u00ED a dom\u00E1c\u00EDch prac\u00ED, soci\u00E1ln\u00ED izolace, probl\u00E9my v zam\u011Bstn\u00E1n\u00ED, \u010Dast\u00E9 pracovn\u00ED neschopnosti, z\u00E1vislost na pomoci jin\u00FDch lid\u00ED, \u00FAzkost a deprese. Vzhledem k v\u00FDrazn\u00E9mu dopadu chronick\u00FDch b\u00E9rcov\u00FDch v\u0159ed\u016F na kvalitu \u017Eivota pacient\u016F, jejich vysok\u00E9 prevalenci v populaci a jejich socioekonomick\u00FDm aspekt\u016Fm je nezbytn\u00E9 vyu\u017E\u00EDt v\u0161echny l\u00E9\u010Debn\u00E9 mo\u017Enosti, kter\u00E9 vedou k rychlej\u0161\u00EDmu hojen\u00ED ulcerac\u00ED. Mikronizovan\u00E1 purifikovan\u00E1 flavonoidn\u00ED frakce (MPFF) signifikantn\u011B zkracuje dobu hojen\u00ED \u017Eiln\u00EDch b\u00E9rcov\u00FDch v\u0159ed\u016F a sou\u010Dasn\u011B zvy\u0161uje po\u010Det zhojen\u00FDch ulcerac\u00ED. Dle nov\u00FDch mezin\u00E1rodn\u00EDch doporu\u010Den\u00ED je MPFF jedin\u00FDm venoaktivn\u00EDm l\u00E9kem, kter\u00FD m\u00E1 prok\u00E1zan\u00FD efekt v terapii \u017Eiln\u00EDch b\u00E9rcov\u00FDch v\u0159ed\u016F (nejvy\u0161\u0161\u00ED stupe\u0148 doporu\u010Den\u00ED 1B)." . "Kvalita \u017Eivota, soci\u00E1ln\u011B-ekonomick\u00E9 aspekty b\u00E9rcov\u00FDch v\u0159ed\u016F a nov\u00E9 mo\u017Enosti celkov\u00E9 terapie" . . "[02D8F1711493]" . . "RIV/00216224:14110/14:00078378" . . . "B\u00E9rcov\u00E9 ulcerace ven\u00F3zn\u00ED etiologie jsou nejt\u011B\u017E\u0161\u00EDm stadiem chronick\u00E9ho \u017Eiln\u00EDho onemocn\u011Bn\u00ED a p\u0159edstavuj\u00ED z\u00E1va\u017En\u00FD zdravotn\u00ED probl\u00E9m. V\u00FDrazn\u011B sni\u017Euj\u00ED kvalitu \u017Eivota pacient\u016F, zejm\u00E9na kv\u016Fli bolesti, sn\u00ED\u017Een\u00E9 mobilit\u011B a poruch\u00E1m sp\u00E1nku. D\u016Fsledkem je ovlivn\u011Bn\u00ED denn\u00EDch aktivit, zejm\u00E9na z\u00E1jmov\u00FDch \u010Dinnost\u00ED a dom\u00E1c\u00EDch prac\u00ED, soci\u00E1ln\u00ED izolace, probl\u00E9my v zam\u011Bstn\u00E1n\u00ED, \u010Dast\u00E9 pracovn\u00ED neschopnosti, z\u00E1vislost na pomoci jin\u00FDch lid\u00ED, \u00FAzkost a deprese. Vzhledem k v\u00FDrazn\u00E9mu dopadu chronick\u00FDch b\u00E9rcov\u00FDch v\u0159ed\u016F na kvalitu \u017Eivota pacient\u016F, jejich vysok\u00E9 prevalenci v populaci a jejich socioekonomick\u00FDm aspekt\u016Fm je nezbytn\u00E9 vyu\u017E\u00EDt v\u0161echny l\u00E9\u010Debn\u00E9 mo\u017Enosti, kter\u00E9 vedou k rychlej\u0161\u00EDmu hojen\u00ED ulcerac\u00ED. Mikronizovan\u00E1 purifikovan\u00E1 flavonoidn\u00ED frakce (MPFF) signifikantn\u011B zkracuje dobu hojen\u00ED \u017Eiln\u00EDch b\u00E9rcov\u00FDch v\u0159ed\u016F a sou\u010Dasn\u011B zvy\u0161uje po\u010Det zhojen\u00FDch ulcerac\u00ED. Dle nov\u00FDch mezin\u00E1rodn\u00EDch doporu\u010Den\u00ED je MPFF jedin\u00FDm venoaktivn\u00EDm l\u00E9kem, kter\u00FD m\u00E1 prok\u00E1zan\u00FD efekt v terapii \u017Eiln\u00EDch b\u00E9rcov\u00FDch v\u0159ed\u016F (nejvy\u0161\u0161\u00ED stupe\u0148 doporu\u010Den\u00ED 1B)."@cs . . "Kvalita \u017Eivota, soci\u00E1ln\u011B-ekonomick\u00E9 aspekty b\u00E9rcov\u00FDch v\u0159ed\u016F a nov\u00E9 mo\u017Enosti celkov\u00E9 terapie"@cs . "Quality of life, socio-economic aspects of venous leg ulcers and new possibilities of systemic treatment"@en . "Va\u0161k\u016F, Vladim\u00EDr" . "CZ - \u010Cesk\u00E1 republika" . . "3" . "quality of life; Venous leg ulcers; Micronized purified flavonoid fraction (MPFF); venoactive drug"@en . . "I" . "2"^^ . "Dermatologie pro praxi" . "25386" . "RIV/00216224:14110/14:00078378!RIV15-MSM-14110___" . "2"^^ . "Quality of life, socio-economic aspects of venous leg ulcers and new possibilities of systemic treatment"@en . . . "8" . "Venous leg ulcers are the latest stage of chronic venous disease and represent a major health problem. They decrease quality of life because of pain, reduced mobility and sleep disturbances. They lead to restriction of daily activities, especially leisure activities and household duties, social isolation, employment problems, working inability, dependence on help of other people, anxiety and depression. Because of big impact of chronic leg ulcers on quality of life, their high prevalence and their socio-economic impact it is necessary to use all the therapeutic possibilities that can lead to faster healing of leg ulcers. Micronized purified flavonoid fraction (MPFF) significantly reduces healing time of venous leg ulcers and it also increases the number of healed leg ulcers. According to new international guidelines, MPFF is the only venoactive drug with proved effect in the treatment of venous leg ulcers (strong recommendation grade 1B)."@en . "Kvalita \u017Eivota, soci\u00E1ln\u011B-ekonomick\u00E9 aspekty b\u00E9rcov\u00FDch v\u0159ed\u016F a nov\u00E9 mo\u017Enosti celkov\u00E9 terapie" . . . . "Kvalita \u017Eivota, soci\u00E1ln\u011B-ekonomick\u00E9 aspekty b\u00E9rcov\u00FDch v\u0159ed\u016F a nov\u00E9 mo\u017Enosti celkov\u00E9 terapie"@cs . "Slonkov\u00E1, Veronika" . .