"Atherosclerosis; genetic factors; interleukin 6; survival analysis; three vessel disease"@en . "93" . . "Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival."@en . "Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival." . "RIV/00216224:14110/14:00078029!RIV15-MSM-14110___" . . "0025-7974" . "Groch, Ladislav" . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests." . "Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival."@en . . . . "[827A1F54DDE2]" . "9"^^ . "Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests."@en . . . "Va\u0161k\u016F, Anna" . "Medicine" . . "3"^^ . . "RIV/00216224:14110/14:00078029" . . "000346762200030" . . "35922" . . . "M\u00E1chal, Jan" . "14110" . "5"^^ . . "28" . "P\u00E1vkov\u00E1 Goldbergov\u00E1, Monika" . "10.1097/MD.0000000000000278" . . . . . "Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival." . "Hlinomaz, Ota" . "P(ED1.100/02/0123), P(VS96097)" .