. "Celiac disease represents inflammatory autoimmune disorder of small intestine caused by gliadin with increasing incidence worldwide. Despite vhe existence of modem diagnostic methods celiac disease remains underdiagnosed. In patients without IgA deficiency, the determination of IgA antibodies against tissue transglutaminase represents the main approach in laboratory screening of patients with suspicion of cellar disease. Detection of IgG antibodies against deamidated gliadin peptides is useful for diagnosis of celiac disease in small children. Nevertheless, some patients with celiac disease do not express the typical serological pattern as we show in following three cases of patients with high suspicion of celiac disease proven by biopsy of small intestine. They had negative IgA antibodies against tissue transglutaminase, but positive in IgG class. In addition, the first patient, unlike the other two, didn't have genetic predisposition to celiac disease (HLA-DQ2, HLA-DQ8)."@en . . "Celiakie je z\u00E1n\u011Btliv\u00E9 autoimunitn\u00ED onemocn\u011Bni tenk\u00E9ho st\u0159eva zp\u016Fsoben\u00E9 lepkem. Jej\u00ED incidence celosv\u011Btov\u011B nar\u016Fst\u00E1. Nicm\u00E9n\u011B i p\u0159es dostupnost modern\u00EDch diagnostick\u00FDch metod celiakie st\u00E1le unik\u00E1 diagn\u00F3ze. V r\u00E1mci diferenci\u00E1ln\u00ED diagnostiky je sou\u010Dasn\u011B t\u0159eba pom\u00FD\u0161let na nov\u00E9 definovanou nosologickou jednotku, glutenovou senzitivitu, kter\u00E1 specifick\u00E9 laboratorn\u00ED parametry nevykazuje a je diagn\u00F3zou per exlusioriern. Z\u00E1kladn\u00EDm laboratorn\u00EDm vy\u0161et\u0159en\u00EDm u pacient\u016F s celiaki\u00ED se p\u0159i zachovan\u00E9 tvorb\u011B celkov\u00FDch imunoglobulin\u016F ve t\u0159\u00EDd\u011B IgA st\u00E1v\u00E1 stanoven\u00ED s\u00E9rov\u00FDch IgA protil\u00E1tek proti tk\u00E1\u0148ov\u00E9 transglutamin\u00E1ze, u men\u0161\u00EDch d\u011Bl\u00ED pak IgG protil\u00E1tek proti deamidovari\u00E9mu gliadinu. Existuj\u00ED v\u0161ak tak\u00E9 pacienti s celiaki\u00ED, kte\u0159\u00ED typick\u00FD serologick\u00FD n\u00E1lez nevykazuj\u00ED. V na\u0161em sd\u011Blen\u00ED proto prezentujeme t\u0159i pacienty s entero-biopticky potvrzen\u00FDm podez\u0159en\u00EDm na celiakii, z nich\u017E v\u0161ichni m\u011Bli negativn\u00ED protil\u00E1tky proti tk\u00E1\u0148ov\u00E9 transglutamin\u00E1ze ve t\u0159\u00EDd\u011B IgA, av\u0161ak pozitivn\u00ED ve t\u0159\u00EDd\u00ED IgG." . "[FE2A33382126]" . . "Celiac disease; autoantibodies; tissue transglutaminase; deamiated gliadin; gluten sensitivity; biopsy"@en . "Atypical laboratory pattern in diagnosis of celiac disease"@en . "Atypick\u00E9 laboratorn\u00ED n\u00E1lezy p\u0159i diagnostice celiakie"@cs . . "Atypick\u00E9 laboratorn\u00ED n\u00E1lezy p\u0159i diagnostice celiakie" . . "Alergie" . "Thon, Vojt\u011Bch" . . . "I" . "6"^^ . . . "14110" . "Hermanov\u00E1, Mark\u00E9ta" . . "3"^^ . . . "RIV/00216224:14110/14:00077711!RIV15-MSM-14110___" . . . "16" . "Barto\u0148kov\u00E1, Dana" . "RIV/00216224:14110/14:00077711" . "Chovancov\u00E1, Zita" . . "Atypick\u00E9 laboratorn\u00ED n\u00E1lezy p\u0159i diagnostice celiakie"@cs . . "1" . "4503" . "CZ - \u010Cesk\u00E1 republika" . . "5"^^ . . "Atypical laboratory pattern in diagnosis of celiac disease"@en . "1212-3536" . . "Celiakie je z\u00E1n\u011Btliv\u00E9 autoimunitn\u00ED onemocn\u011Bni tenk\u00E9ho st\u0159eva zp\u016Fsoben\u00E9 lepkem. Jej\u00ED incidence celosv\u011Btov\u011B nar\u016Fst\u00E1. Nicm\u00E9n\u011B i p\u0159es dostupnost modern\u00EDch diagnostick\u00FDch metod celiakie st\u00E1le unik\u00E1 diagn\u00F3ze. V r\u00E1mci diferenci\u00E1ln\u00ED diagnostiky je sou\u010Dasn\u011B t\u0159eba pom\u00FD\u0161let na nov\u00E9 definovanou nosologickou jednotku, glutenovou senzitivitu, kter\u00E1 specifick\u00E9 laboratorn\u00ED parametry nevykazuje a je diagn\u00F3zou per exlusioriern. Z\u00E1kladn\u00EDm laboratorn\u00EDm vy\u0161et\u0159en\u00EDm u pacient\u016F s celiaki\u00ED se p\u0159i zachovan\u00E9 tvorb\u011B celkov\u00FDch imunoglobulin\u016F ve t\u0159\u00EDd\u011B IgA st\u00E1v\u00E1 stanoven\u00ED s\u00E9rov\u00FDch IgA protil\u00E1tek proti tk\u00E1\u0148ov\u00E9 transglutamin\u00E1ze, u men\u0161\u00EDch d\u011Bl\u00ED pak IgG protil\u00E1tek proti deamidovari\u00E9mu gliadinu. Existuj\u00ED v\u0161ak tak\u00E9 pacienti s celiaki\u00ED, kte\u0159\u00ED typick\u00FD serologick\u00FD n\u00E1lez nevykazuj\u00ED. V na\u0161em sd\u011Blen\u00ED proto prezentujeme t\u0159i pacienty s entero-biopticky potvrzen\u00FDm podez\u0159en\u00EDm na celiakii, z nich\u017E v\u0161ichni m\u011Bli negativn\u00ED protil\u00E1tky proti tk\u00E1\u0148ov\u00E9 transglutamin\u00E1ze ve t\u0159\u00EDd\u011B IgA, av\u0161ak pozitivn\u00ED ve t\u0159\u00EDd\u00ED IgG."@cs . "Atypick\u00E9 laboratorn\u00ED n\u00E1lezy p\u0159i diagnostice celiakie" . "Kozumpl\u00EDkov\u00E1, Romana" .