"52590" . "14110" . . . . "Bulik, Martin" . "1036" . "000334291900006" . . "Objective: Large artery occlusion (LAO) in patients with major stroke predicts poor revascularization by intravenous thrombolysis (IVT) and more likely results in a poor outcome. We focused on the effects of intra- arterial thrombolysis (IAT) and endovascular mechanical recanalization (EMR) as rescue therapies in major strokes refractory to IVT. Methods: A retrospective analysis of 87 patients (National Institutes of Health Stroke Scale >20), who did not respond to full-dose IVT due to LAO, was performed based on their endovascular therapy status. IAT was performed as an intraclot infusion of alteplase, and EMR was provided by the Solitaire device (TM) (Covidien, Dubin, Ireland). The recanalization and 3-month outcome rates after IAT/EMR were correlated with a group of patients who were scheduled to receive endovascular treatment but who underwent only IVT. Results: We achieved successful recanalization by IAT and EMR in 68.7% and 76.1% of patients, respectively." . "9"^^ . . "ACUTE ISCHEMIC-STROKE; MECHANICAL THROMBECTOMY; RECANALIZATION; VALIDATION; RETRIEVER"@en . "I, P(ED1.100/02/0123)" . "Van\u00ED\u010Dek, Ji\u0159\u00ED" . . . "Objective: Large artery occlusion (LAO) in patients with major stroke predicts poor revascularization by intravenous thrombolysis (IVT) and more likely results in a poor outcome. We focused on the effects of intra- arterial thrombolysis (IAT) and endovascular mechanical recanalization (EMR) as rescue therapies in major strokes refractory to IVT. Methods: A retrospective analysis of 87 patients (National Institutes of Health Stroke Scale >20), who did not respond to full-dose IVT due to LAO, was performed based on their endovascular therapy status. IAT was performed as an intraclot infusion of alteplase, and EMR was provided by the Solitaire device (TM) (Covidien, Dubin, Ireland). The recanalization and 3-month outcome rates after IAT/EMR were correlated with a group of patients who were scheduled to receive endovascular treatment but who underwent only IVT. Results: We achieved successful recanalization by IAT and EMR in 68.7% and 76.1% of patients, respectively."@en . "BRITISH JOURNAL OF RADIOLOGY" . . "Brichta, Jaroslav" . . . . . . . "RIV/00216224:14110/14:00077147" . . "Utility of a rescue endovascular therapy for the treatment of major strokes refractory to full-dose intravenous thrombolysis" . "10.1259/bjr.20130545" . "Utility of a rescue endovascular therapy for the treatment of major strokes refractory to full-dose intravenous thrombolysis" . "0007-1285" . "87" . . . . "Utility of a rescue endovascular therapy for the treatment of major strokes refractory to full-dose intravenous thrombolysis"@en . "[105E67B2D335]" . "4"^^ . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Jan\u010D\u00E1lek, Radim" . "3"^^ . "Utility of a rescue endovascular therapy for the treatment of major strokes refractory to full-dose intravenous thrombolysis"@en . "RIV/00216224:14110/14:00077147!RIV15-MSM-14110___" .