. . "Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. Since there is little information on how AGR3 is expressed in normal and diseased tissues and what its exact function is, we analyzed its expression pattern in normal liver and tumor tissue of ICC and HCC. The immunohistochemical analysis in normal tissue revealed specific AGR3 expression in intrahepatic bile duct cholangiocytes which was not present in liver hepatocytes." . "10.1016/j.yexmp.2014.04.002" . . "[44F7B8C6AC02]" . "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma." . "3" . "Nov\u00E1k, Ji\u0159\u00ED" . "Hermanov\u00E1, Mark\u00E9ta" . . "000337212600016" . . . "\u017Dampachov\u00E1, V\u00EDta" . "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma." . "14110" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma."@en . "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma" . "7"^^ . "2"^^ . . "I" . . "Brychtov\u00E1, Veronika" . . "96" . . "RIV/00216224:14110/14:00077103!RIV15-MSM-14110___" . "Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma."@en . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . . . "0014-4800" . . . "11485" . "RIV/00216224:14110/14:00077103" . . "Hrstka, Roman" . "Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. Since there is little information on how AGR3 is expressed in normal and diseased tissues and what its exact function is, we analyzed its expression pattern in normal liver and tumor tissue of ICC and HCC. The immunohistochemical analysis in normal tissue revealed specific AGR3 expression in intrahepatic bile duct cholangiocytes which was not present in liver hepatocytes."@en . . "AGR3; GPC-3; Intrahepatic cholangiocarcinoma; Hepatocellular carcinoma; Mucopolysaccharides; Immunohistochemistry"@en . "Fabian, Pavel" . . "7"^^ .