. . "7330" . "CIRKADI\u00C1NN\u00CD DISRUPTORY A JEJICH V\u00DDZNAM V PRIM\u00C1RN\u00CD PREVENCI" . "I" . "CIRKADI\u00C1NN\u00CD DISRUPTORY A JEJICH V\u00DDZNAM V PRIM\u00C1RN\u00CD PREVENCI" . "CIRKADI\u00C1NN\u00CD DISRUPTORY A JEJICH V\u00DDZNAM V PRIM\u00C1RN\u00CD PREVENCI"@cs . . "CIRCADIAN DISRUPTORS AND THEIR IMPORTANCE IN PRIMARY PREVENTION"@en . . . "CIRKADI\u00C1NN\u00CD DISRUPTORY A JEJICH V\u00DDZNAM V PRIM\u00C1RN\u00CD PREVENCI"@cs . "RIV/00216224:14110/14:00075748!RIV15-MSM-14110___" . "circadian rhythms; endocrine disruptors (F.CD); melatonin; disease prevention"@en . "59" . . . "Hrub\u00E1, Drahoslava" . "CIRCADIAN DISRUPTORS AND THEIR IMPORTANCE IN PRIMARY PREVENTION"@en . . . "Biologick\u00E9 cirkadi\u00E1nn\u00ED hodiny maj\u00ED v\u0161ichni obratlovci, v\u010Detn\u011B \u010Dlov\u011Bka. Jejich receptory jsou na o\u010Dn\u00ED s\u00EDtnici, informace o st\u0159\u00EDd\u00E1n\u00ED dne a noci jsou vedeny do centra v hypothalamu a odtud do epif\u00FDxy. Ta produkuje hormon melatonin (N-acetyl-5-metoxytryptamin), t\u00E9m\u011B\u0159 v\u00FDhradn\u011B v obdob\u00ED tmav\u00E9 \u010D\u00E1st\u00ED dne. Hormon je rychle vyplavov\u00E1n do krve a moxkom\u00ED\u0161n\u00EDho moku a je bexprost\u0159edn\u00EDm nosi\u010Dem informace o f\u00E1xi cirkadi\u00E1nn\u00EDho cyklu bu\u0148k\u00E1m cel\u00E9ho t\u011Bla, kter\u00E9 pod\u0159ixuj\u00ED fyziologick\u00E9 funkce org\u00E1n\u016F a organismu st\u0159\u00EDd\u00E1n\u00ED dne a noci. Podle dosavadn\u00EDch v\u00FDxkum\u016F se melatonin \u00FA\u010Dastn\u00ED \u0159ady v\u00FDxnamn\u00FDch fyziologick\u00FDch funkc\u00ED: regulace sp\u00E1nku a cirkadi\u00E1nn\u00EDch rytm\u016F, n\u00E1lady, imunitn\u00ED, onkostatick\u010D a antioxida\u010Dn\u00ED aktivity. Synt\u00E9za melatoninu kles\u00E1 s v\u011Bkem. Um\u011Bl\u00E9 osv\u011Btlen\u00ED ve\u010Der nebo brzy r\u00E1no zkracuje tmavou \u010D\u00E1st dne, tak\u00E9 jen kr\u00E1tkodob\u00E9 rozsv\u00EDcen\u00ED v noci redukuje mno\u017Estv\u00ED melatoninu produkovan\u00E9ho b\u011Bhem 24 hodin. Synt\u00E9zu melatoninu v\u00FDznamn\u011B naru\u0161uje leteck\u00FD p\u0159esun p\u0159es n\u011Bkolik \u010Dasov\u00FDch z\u00F3n." . "1802-6281" . . "1" . "1"^^ . . . "All vertebrates, including humans, have a biological circadian clock. Their receptors are located on the retina, and information regarding the alternation of day and night are transferred to a centre in the hypothalamus and from there into the pineal gland which produces melatonin (N-acetyl-5-metoxytryptamin), almost exclusively during the hours of darkness. The hormone is quickly discharged into the bloodstream and cerebrospinal fluid into all cells. Such immediate information about the circadian phase of day/night changes allows to organs and organism to regulate their physiological functions. Current research suggests that melatonin is involved in several important physiological functions: sleep regulation and circadian rhythms, mood, immunity, oncostatic and antioxidant activities. Synthesis of melatonin reduces with age."@en . "1"^^ . . "Biologick\u00E9 cirkadi\u00E1nn\u00ED hodiny maj\u00ED v\u0161ichni obratlovci, v\u010Detn\u011B \u010Dlov\u011Bka. Jejich receptory jsou na o\u010Dn\u00ED s\u00EDtnici, informace o st\u0159\u00EDd\u00E1n\u00ED dne a noci jsou vedeny do centra v hypothalamu a odtud do epif\u00FDxy. Ta produkuje hormon melatonin (N-acetyl-5-metoxytryptamin), t\u00E9m\u011B\u0159 v\u00FDhradn\u011B v obdob\u00ED tmav\u00E9 \u010D\u00E1st\u00ED dne. Hormon je rychle vyplavov\u00E1n do krve a moxkom\u00ED\u0161n\u00EDho moku a je bexprost\u0159edn\u00EDm nosi\u010Dem informace o f\u00E1xi cirkadi\u00E1nn\u00EDho cyklu bu\u0148k\u00E1m cel\u00E9ho t\u011Bla, kter\u00E9 pod\u0159ixuj\u00ED fyziologick\u00E9 funkce org\u00E1n\u016F a organismu st\u0159\u00EDd\u00E1n\u00ED dne a noci. Podle dosavadn\u00EDch v\u00FDxkum\u016F se melatonin \u00FA\u010Dastn\u00ED \u0159ady v\u00FDxnamn\u00FDch fyziologick\u00FDch funkc\u00ED: regulace sp\u00E1nku a cirkadi\u00E1nn\u00EDch rytm\u016F, n\u00E1lady, imunitn\u00ED, onkostatick\u010D a antioxida\u010Dn\u00ED aktivity. Synt\u00E9za melatoninu kles\u00E1 s v\u011Bkem. Um\u011Bl\u00E9 osv\u011Btlen\u00ED ve\u010Der nebo brzy r\u00E1no zkracuje tmavou \u010D\u00E1st dne, tak\u00E9 jen kr\u00E1tkodob\u00E9 rozsv\u00EDcen\u00ED v noci redukuje mno\u017Estv\u00ED melatoninu produkovan\u00E9ho b\u011Bhem 24 hodin. Synt\u00E9zu melatoninu v\u00FDznamn\u011B naru\u0161uje leteck\u00FD p\u0159esun p\u0159es n\u011Bkolik \u010Dasov\u00FDch z\u00F3n."@cs . "5"^^ . . "RIV/00216224:14110/14:00075748" . "14110" . "[28E619329D13]" . "Hygiena" . . "CZ - \u010Cesk\u00E1 republika" .