. "Jarkovsk\u00FD, Ji\u0159\u00ED" . "Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e can distinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%."@en . . "Adam, Zden\u011Bk" . . "[A403769118A8]" . . "Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance"@en . . "Kugl\u00EDk, Petr" . . "Kubiczkov\u00E1, Lenka" . "Kryukov, Fedor" . "IT - Italsk\u00E1 republika" . . "10"^^ . "Pour, Lud\u011Bk" . "14"^^ . "\u0160ev\u010D\u00EDkov\u00E1, Sabina" . . . "Slab\u00FD, Ond\u0159ej" . "14110" . . "Nekvindov\u00E1, Jana" . "Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance" . . . "Gre\u0161likov\u00E1, Henrieta" . . "8"^^ . "H\u00E1jek, Roman" . . "Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e can distinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%." . . . "Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance"@en . "Vete\u0161n\u00EDkov\u00E1, Eva" . . "RIV/00216224:14110/14:00075513!RIV15-MSM-14110___" . . . . "99" . . "0390-6078" . "7322" . "Haematologica/the hematology journal" . . "Multiple myeloma; MGUS; circulating miRNA; miRNA profiling; qPCR"@en . . "Radov\u00E1, Lenka" . . "000336255000022" . . . . "RIV/00216224:14110/14:00075513" . "I, P(7E12070), P(NT13190), Z(MSM0021622434)" . "10.3324/haematol.2013.093500" . . . "Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance" . "Kryukova, Elena Vladimirovna" . . "3" .