"4"^^ . "Psychosis effect on hippocampal reduction in schizophrenia" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . "4"^^ . . "48" . . . "Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV."@en . "Psychosis effect on hippocampal reduction in schizophrenia"@en . "Psychosis effect on hippocampal reduction in schizophrenia" . . "H\u00FD\u017Ea, Martin" . "H\u00FCttlov\u00E1, Jitka" . . "Progress in Neuro-Psychopharmacology and Biological Psychiatry" . . "7"^^ . . "40830" . . "0278-5846" . "Psychosis effect on hippocampal reduction in schizophrenia"@en . . "I" . . . "Ka\u0161p\u00E1rek, Tom\u00E1\u0161" . "[01C40DFDB16D]" . "Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV." . "10.1016/j.pnpbp.2013.10.008" . "000328074200027" . . . "14110" . . "RIV/00216224:14110/14:00075026" . . "RIV/00216224:14110/14:00075026!RIV15-MSM-14110___" . "3 Jan 2014" . "hippocampus; morphometry; psychosis; schizophrenia; toxicity"@en . . "Ke\u0159kovsk\u00FD, Milo\u0161" .