. . "Anti-tumor properties; Cancer risk reduction; Cancer therapy; Carcinogenesis; Chemoprevention; Statins"@en . "Statins in oncological research: From experimental studies to clinical practice"@en . . . . "Jel\u00EDnkov\u00E1, \u0160\u00E1rka" . . . "Critical Reviews in Oncology/Hematology" . "000347130000012" . "5"^^ . . . "RIV/00216224:14110/14:00074348!RIV15-MSM-14110___" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "14110" . "Rotrekl, Vladim\u00EDr" . . "10.1016/j.critrevonc.2014.08.002" . "Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many epidemiological and preclinical studies pointed to anti-tumor properties of statins, including anti-proliferative activities, apoptosis, decreased angiogenesis and metastasis. These processes play an important role in carcinogenesis and, therefore, the role of statins in cancer disease is being seriously discussed among oncologists. Anti-neoplastic properties of statins combined with an acceptable toxicity profile in the majority of individuals support their further development as anti-tumor drugs.The mechanism of action, current preclinical studies and clinical efficacy of statins are reviewed in this paper. Moreover, promising results have been reported regarding the statins' efficacy in some cancer types, especially in esophageal and colorectal cancers, and hepatocellular carcinoma." . . "92" . . . . "47310" . "Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many epidemiological and preclinical studies pointed to anti-tumor properties of statins, including anti-proliferative activities, apoptosis, decreased angiogenesis and metastasis. These processes play an important role in carcinogenesis and, therefore, the role of statins in cancer disease is being seriously discussed among oncologists. Anti-neoplastic properties of statins combined with an acceptable toxicity profile in the majority of individuals support their further development as anti-tumor drugs.The mechanism of action, current preclinical studies and clinical efficacy of statins are reviewed in this paper. Moreover, promising results have been reported regarding the statins' efficacy in some cancer types, especially in esophageal and colorectal cancers, and hepatocellular carcinoma."@en . . . "1040-8428" . "Statins in oncological research: From experimental studies to clinical practice" . "P(7AMB13FR011), P(ED1.100/02/0123), P(GA13-19910S), P(GBP302/12/G157)" . "Kubatka, Peter" . "Statins in oncological research: From experimental studies to clinical practice"@en . . "3" . . "Kru\u017Eliak, Peter" . . "[EB9A70198592]" . "Mladosievicova, Beata" . "RIV/00216224:14110/14:00074348" . "16"^^ . "Statins in oncological research: From experimental studies to clinical practice" . . . "2"^^ . .