"RIV/00216224:14110/14:00073433!RIV15-MSM-14110___" . "10"^^ . "Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples."@en . . "21116" . "Kryukova, Elena Vladimirovna" . . "P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190), P(NT13492), Z(MSM0021622434)" . . . "Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples." . . "8"^^ . "Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH"@en . "Gre\u0161likov\u00E1, Henrieta" . "RIV/00216224:14110/14:00073433" . . . "[B71A4E0B141E]" . . . "multiple myeloma; CD19+; CD138+; cytogenetics; array-CGH; FISH"@en . "Kryukov, Fedor" . . "N\u011Bmec, Pavel" . "000329769500007" . . "Kupsk\u00E1, Renata" . . . . . "Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH"@en . . "Kugl\u00EDk, Petr" . . . . "14110" . . . "1" . "Ihnatov\u00E1, Ivana" . "Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH" . "61" . "SK - Slovensk\u00E1 republika" . "Smetana, Jan" . . . . "Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH" . . . "Neoplasma" . . . . "10.4149/neo_2014_008" . "Mikul\u00E1\u0161ov\u00E1, Aneta" . "H\u00E1jek, Roman" . "0028-2685" . . "10"^^ . . . .