"Gastroenterologie a hepatologie" . "Such\u00E1nek, \u0160." . "14110" . . "V\u00FDvojov\u00E1 stadia kolorekt\u00E1ln\u00EDho karcinomu (adenomy) jsou ur\u010Dena histopatologick\u00FDm stagingem, kter\u00FD ur\u010Duje m\u00EDru rizika vzniku karcinomu. Rekurence kolorekt\u00E1ln\u00EDch adenom\u016F zvy\u0161uje n\u00E1roky na dispenzarizaci pacient\u016F. Proces malign\u00ED transformace z norm\u00E1ln\u00ED tk\u00E1n\u011B je prov\u00E1zen charakteristick\u00FDmi zm\u011Bnami na \u00FArovni genetick\u00FDch a epigenetick\u00FDch poruch. Hlavn\u00EDm c\u00EDlem studie bylo dlouhodob\u00E9(6\u201311 let) sledov\u00E1n\u00ED pacient\u016F po endoskopick\u00E9 polypektomii, p\u0159edev\u0161\u00EDm vzhledem k v\u00FDskytu n\u00E1sledn\u00FDch (rekurentn\u00EDch)adenom\u016F. Dal\u0161\u00EDm c\u00EDlem bylo sledov\u00E1n\u00ED genetick\u00E9ho profilu nej\u010Dast\u011Bj\u0161\u00EDch somatick\u00FDch DNA mutac\u00ED a jejich p\u0159\u00EDpadn\u00FD vztah k histologick\u00E9 charakteristice adenom\u016F. Materi\u00E1l a metody: Do studie byli za\u0159azeni pacienti, kte\u0159\u00ED v letech 2002\u20132006 podstoupili kolonoskopick\u00E9 vy\u0161et\u0159en\u00ED s odstran\u011Bn\u00EDm adenomov\u00E9ho polypu." . "[8F521DB75077]" . "Du\u0161ek, Ladislav" . "Bene\u0161ov\u00E1, L." . "V\u00FDvojov\u00E1 stadia kolorekt\u00E1ln\u00EDho karcinomu (adenomy) jsou ur\u010Dena histopatologick\u00FDm stagingem, kter\u00FD ur\u010Duje m\u00EDru rizika vzniku karcinomu. Rekurence kolorekt\u00E1ln\u00EDch adenom\u016F zvy\u0161uje n\u00E1roky na dispenzarizaci pacient\u016F. Proces malign\u00ED transformace z norm\u00E1ln\u00ED tk\u00E1n\u011B je prov\u00E1zen charakteristick\u00FDmi zm\u011Bnami na \u00FArovni genetick\u00FDch a epigenetick\u00FDch poruch. Hlavn\u00EDm c\u00EDlem studie bylo dlouhodob\u00E9(6\u201311 let) sledov\u00E1n\u00ED pacient\u016F po endoskopick\u00E9 polypektomii, p\u0159edev\u0161\u00EDm vzhledem k v\u00FDskytu n\u00E1sledn\u00FDch (rekurentn\u00EDch)adenom\u016F. Dal\u0161\u00EDm c\u00EDlem bylo sledov\u00E1n\u00ED genetick\u00E9ho profilu nej\u010Dast\u011Bj\u0161\u00EDch somatick\u00FDch DNA mutac\u00ED a jejich p\u0159\u00EDpadn\u00FD vztah k histologick\u00E9 charakteristice adenom\u016F. Materi\u00E1l a metody: Do studie byli za\u0159azeni pacienti, kte\u0159\u00ED v letech 2002\u20132006 podstoupili kolonoskopick\u00E9 vy\u0161et\u0159en\u00ED s odstran\u011Bn\u00EDm adenomov\u00E9ho polypu."@cs . . "Min\u00E1rikov\u00E1, P." . . "I" . . "Zavoral, M." . "1804-7874" . . . "1"^^ . "Impact of clinical and molecular factors on the estimation of colorectal adenomatous polyps recurrence in long-term clinical follow-up patients"@en . "5" . . "Hrabal, P." . . "Vliv klinick\u00FDch a molekul\u00E1rn\u00EDch faktor\u016F na odhad rekurence kolorekt\u00E1ln\u00EDch adenom\u016F u dlouhodob\u011B sledovan\u00FDch pacient\u016F" . "Impact of clinical and molecular factors on the estimation of colorectal adenomatous polyps recurrence in long-term clinical follow-up patients"@en . "Fri\u010D, P." . . "6"^^ . "Vliv klinick\u00FDch a molekul\u00E1rn\u00EDch faktor\u016F na odhad rekurence kolorekt\u00E1ln\u00EDch adenom\u016F u dlouhodob\u011B sledovan\u00FDch pacient\u016F" . "9"^^ . . . . "Vliv klinick\u00FDch a molekul\u00E1rn\u00EDch faktor\u016F na odhad rekurence kolorekt\u00E1ln\u00EDch adenom\u016F u dlouhodob\u011B sledovan\u00FDch pacient\u016F"@cs . . "Colorectal neoplasms development stages (adenomas) are determined by histopathological staging assessing the risk level of cancer development. Colorectal adenomas recurrence increases the requirements for patients\u2019 follow-up. The malignant transformation process of the normal tissue is accompanied by characteristic changes of the level of genetic and epigenetic disorders. The main study objective was a long-term (6\u201311 years) monitoring of patients after endoscopic polypectomy, mainly in relation to the presence of recurrent adenomas. Another goal was to study the genetic profile of the most common somatic DNA copy number variations and their possible relation to adenoma histopathology characteristics. Material and methods: Patients included in the study went through a colonoscopy examination with their adenomas removed in the period of 2002\u20132006."@en . "RIV/00216224:14110/13:00070621!RIV14-MSM-14110___" . . . "Min\u00E1rik, M." . "RIV/00216224:14110/13:00070621" . "67" . "Vliv klinick\u00FDch a molekul\u00E1rn\u00EDch faktor\u016F na odhad rekurence kolorekt\u00E1ln\u00EDch adenom\u016F u dlouhodob\u011B sledovan\u00FDch pacient\u016F"@cs . "colorectal neoplasms; adenoma; cancerogenesis; DNA copy number variations"@en . "CZ - \u010Cesk\u00E1 republika" . "Bel\u0161\u00E1nov\u00E1, B." . . "114473" .