"2"^^ . "Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e."@en . "Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases"@en . "1"^^ . . . "Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e." . . . . "14110" . "10.4161/jkst.23810" . "2" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "4"^^ . . . . "P(7AMB12AT019), P(ED1.100/02/0123)" . . . "Sou\u010Dek, Karel" . "2162-3996" . "Va\u0148hara, Petr" . . "Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases" . "metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment"@en . "Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases"@en . . "[1FBD70BE44FE]" . "2" . . . . "Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases" . "90247" . "RIV/00216224:14110/13:00067733!RIV14-MSM-14110___" . . "JAK-STAT" . . . "RIV/00216224:14110/13:00067733" . . . .