. . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "7"^^ . "R\u00E1\u010Dil, Zden\u011Bk" . . "Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants." . . "6"^^ . "[4C6EC45B7FEA]" . "54" . . "PROGNOSIS; FREQUENT"@en . "To\u0161kov\u00E1, Martina" . . "Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants."@en . . . "Timilsina, Shira" . . "Leukemia & Lymphoma" . . "Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene" . "101206" . "Dvo\u0159\u00E1kov\u00E1, Dana" . . . . "1042-8194" . "Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene" . "Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene"@en . . . "4"^^ . "I" . "Mayer, Ji\u0159\u00ED" . . "RIV/00216224:14110/13:00067476" . "R\u00E1zga, Filip" . "000315898100032" . "Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene"@en . "RIV/00216224:14110/13:00067476!RIV14-MSM-14110___" . "4" . . "Je\u017E\u00ED\u0161kov\u00E1, Ivana" . "14110" . . . "10.3109/10428194.2012.727414" .