"Krej\u010D\u00ED, Marta" . "4"^^ . . . . . "5" . "103921" . "0300-8916" . "Tumori" . . . . . . . . "Salvage lenalidomide in four rare oncological diseases"@en . "6"^^ . "I, P(NT12215), P(NT13190)" . "Szturz, Petr" . "Langerhans cell histiocytosis; Erdheim-Chester disease; angiomatosis; Castleman disease"@en . "14110" . . . "Mayer, Ji\u0159\u00ED" . . "Salvage lenalidomide in four rare oncological diseases" . "In rare disorders, there are often no standard therapy recommendations. Patients with refractory disease may require novel experimental approaches. Applied as second- up to fourth-line treatment, lenalidomide (10-25 mg perorally on days 1-21 in a 28-day cycle) was used in our cohort of four adult patients with aggressive, multisystem and relapsing diseases. Complete and long-lasting remissions (more than 1 year, no maintenance therapy) were achieved in patients with Langerhans cell histiocytosis (11 cycles, combination with dexamethasone and etoposide, consolidated by allogeneic blood stem cell transplant) and plasma-cell Castleman disease (15 cycles, monotherapy). Mixed response with complete disappearance of brain infiltrates was reached in Erdheim-Chester disease (6 cycles, monotherapy) and gastrointestinal bleeding was well controlled in multiple angiomatosis (9 cycles, combination with thalidomide)."@en . . "In rare disorders, there are often no standard therapy recommendations. Patients with refractory disease may require novel experimental approaches. Applied as second- up to fourth-line treatment, lenalidomide (10-25 mg perorally on days 1-21 in a 28-day cycle) was used in our cohort of four adult patients with aggressive, multisystem and relapsing diseases. Complete and long-lasting remissions (more than 1 year, no maintenance therapy) were achieved in patients with Langerhans cell histiocytosis (11 cycles, combination with dexamethasone and etoposide, consolidated by allogeneic blood stem cell transplant) and plasma-cell Castleman disease (15 cycles, monotherapy). Mixed response with complete disappearance of brain infiltrates was reached in Erdheim-Chester disease (6 cycles, monotherapy) and gastrointestinal bleeding was well controlled in multiple angiomatosis (9 cycles, combination with thalidomide)." . "10.1700/1377.15326" . . . "[3A458B6AC2C6]" . "Salvage lenalidomide in four rare oncological diseases"@en . "RIV/00216224:14110/13:00065660" . "Rehak, Zdenek" . "Salvage lenalidomide in four rare oncological diseases" . "Adam, Zden\u011Bk" . "8"^^ . "IT - Italsk\u00E1 republika" . . "Koukalova, Renata" . . . "RIV/00216224:14110/13:00065660!RIV14-MZ0-14110___" . "99" . . "Moulis, Mojm\u00EDr" . . "K\u0159en, Leo\u0161" .