"5"^^ . "14110" . "\u010Cervinek, Libor" . . . "Pejchalov\u00E1, A." . "Nemoc chladov\u00FDch aglutinin\u016F nereaguj\u00EDc\u00ED na l\u00E9\u010Dbu glukokortikoidy a na l\u00E9\u010Dbu rituximabem. Jak\u00FD postup zvolit pro III. linii l\u00E9\u010Dby? Popis p\u0159\u00EDpadu a p\u0159ehled literatury"@cs . "Autoimmune haemolytic anaemia; Bendamustin; Bortezomib; Cold agglutinin disease; Cyclophosphamide; Eculizumab; Fludarabin; Rituximab; Waldenstr\u00F6m macroglobulinemia"@en . . "Acquired autoimmune haemolytic anaemia is divided according to the characteristics of immunoglobulin causing haemolysis. The most frequent are haemolytic anaemia with thermal antibodies. They bind to erythrocytes and initiate their destruction in the reticuloendothelial system cells, leading to extravascular haemolysis. Cold agglutinin disease differs significantly from haemolytic anaemia with thermal antibodies. Agglutination is caused by monoclonal antibodies, in most cases class IgM and very rarely class IgG. Under cold conditions they bind to erythrocytes and cause their agglutination and subsequent disorder of blood circulation in body parts with a lower temperature. Agglutinins binding initiate the binding of the complement to the erythrocytes. Under warm conditions the binding becomes loose but the parts of the complement, which are already bound, cause haemolysis, which is mainly of an intravascular nature. The loose haemoglobin causes haemoglobinuria."@en . "Chlupov\u00E1, G." . . . "13"^^ . "Nemoc chladov\u00FDch aglutinin\u016F nereaguj\u00EDc\u00ED na l\u00E9\u010Dbu glukokortikoidy a na l\u00E9\u010Dbu rituximabem. Jak\u00FD postup zvolit pro III. linii l\u00E9\u010Dby? Popis p\u0159\u00EDpadu a p\u0159ehled literatury"@cs . . "0042-773X" . "Mayer, Ji\u0159\u00ED" . "Nemoc chladov\u00FDch aglutinin\u016F nereaguj\u00EDc\u00ED na l\u00E9\u010Dbu glukokortikoidy a na l\u00E9\u010Dbu rituximabem. Jak\u00FD postup zvolit pro III. linii l\u00E9\u010Dby? Popis p\u0159\u00EDpadu a p\u0159ehled literatury" . "9" . . "Nemoc chladov\u00FDch aglutinin\u016F nereaguj\u00EDc\u00ED na l\u00E9\u010Dbu glukokortikoidy a na l\u00E9\u010Dbu rituximabem. Jak\u00FD postup zvolit pro III. linii l\u00E9\u010Dby? Popis p\u0159\u00EDpadu a p\u0159ehled literatury" . "Z\u00EDskan\u00E9 autoimunitn\u00ED hemolytick\u00E9 an\u00E9mie se d\u011Bl\u00ED dle vlastnost\u00ED imunoglobulin\u016F, kter\u00E9 hemol\u00FDzu vyvol\u00E1vaj\u00ED. Nej\u010Dast\u011Bj\u0161\u00ED jsou hemolytick\u00E9 an\u00E9mie s tepeln\u00FDmi protil\u00E1tkami. Ty se v\u00E1\u017E\u00ED na erytrocyty a nastartuj\u00ED jejich destrukci v bu\u0148k\u00E1ch retikuloendotelov\u00E9ho syst\u00E9mu. Jde tedy o extravaskul\u00E1rn\u00ED hemol\u00FDzu. Nemoc chladov\u00FDch aglutinin\u016F se od klasick\u00E9 autoimunitn\u00ED an\u00E9mie s tepeln\u00FDmi protil\u00E1tkami z\u00E1sadn\u011B li\u0161\u00ED. Aglutinaci zp\u016Fsobuj\u00ED monoklon\u00E1ln\u00ED protil\u00E1tky, ve v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F t\u0159\u00EDdy IgM, zcela v\u00FDjime\u010Dn\u011B IgG. Ty se v chladu v\u00E1\u017E\u00ED na erytrocyty a zp\u016Fsobuj\u00ED jejich aglutinaci, a t\u00EDm poruchu prokrven\u00ED \u010D\u00E1st\u00ED t\u011Bla s ni\u017E\u0161\u00ED teplotou. Vazba aglutinin\u016F iniciuje vazbu komplementu na erytrocyty. V teple se aglutininy uvoln\u00ED, ale nav\u00E1zan\u00E9 \u010D\u00E1sti komplementu ji\u017E zp\u016Fsob\u00ED hemol\u00FDzu, kter\u00E1 je p\u0159ev\u00E1\u017En\u011B intravaskul\u00E1rn\u00ED. Uvoln\u011Bn\u00FD hemoglobin zp\u016Fsobuje hemoglobinurii. Popisujeme pacienta s touto nemoc\u00ED."@cs . . . . "CZ - \u010Cesk\u00E1 republika" . "Cold agglutinin disease - No response to glucocorticoids and rituximab, what treatment is best for the 3rd line of therapy? Case report and review of the literature"@en . . "P(NT12130), P(NT12215), P(NT13190)" . "Adam, Zden\u011Bk" . . . "Z\u00EDskan\u00E9 autoimunitn\u00ED hemolytick\u00E9 an\u00E9mie se d\u011Bl\u00ED dle vlastnost\u00ED imunoglobulin\u016F, kter\u00E9 hemol\u00FDzu vyvol\u00E1vaj\u00ED. Nej\u010Dast\u011Bj\u0161\u00ED jsou hemolytick\u00E9 an\u00E9mie s tepeln\u00FDmi protil\u00E1tkami. Ty se v\u00E1\u017E\u00ED na erytrocyty a nastartuj\u00ED jejich destrukci v bu\u0148k\u00E1ch retikuloendotelov\u00E9ho syst\u00E9mu. Jde tedy o extravaskul\u00E1rn\u00ED hemol\u00FDzu. Nemoc chladov\u00FDch aglutinin\u016F se od klasick\u00E9 autoimunitn\u00ED an\u00E9mie s tepeln\u00FDmi protil\u00E1tkami z\u00E1sadn\u011B li\u0161\u00ED. Aglutinaci zp\u016Fsobuj\u00ED monoklon\u00E1ln\u00ED protil\u00E1tky, ve v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F t\u0159\u00EDdy IgM, zcela v\u00FDjime\u010Dn\u011B IgG. Ty se v chladu v\u00E1\u017E\u00ED na erytrocyty a zp\u016Fsobuj\u00ED jejich aglutinaci, a t\u00EDm poruchu prokrven\u00ED \u010D\u00E1st\u00ED t\u011Bla s ni\u017E\u0161\u00ED teplotou. Vazba aglutinin\u016F iniciuje vazbu komplementu na erytrocyty. V teple se aglutininy uvoln\u00ED, ale nav\u00E1zan\u00E9 \u010D\u00E1sti komplementu ji\u017E zp\u016Fsob\u00ED hemol\u00FDzu, kter\u00E1 je p\u0159ev\u00E1\u017En\u011B intravaskul\u00E1rn\u00ED. Uvoln\u011Bn\u00FD hemoglobin zp\u016Fsobuje hemoglobinurii. Popisujeme pacienta s touto nemoc\u00ED." . . . . "59" . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . "Kr\u00E1l, Zden\u011Bk" . "Cold agglutinin disease - No response to glucocorticoids and rituximab, what treatment is best for the 3rd line of therapy? Case report and review of the literature"@en . . "\u0158\u00EDhov\u00E1, L." . "[09EF999FF863]" . . "91294" . "Pour, Lud\u011Bk" . . "Krej\u010D\u00ED, Marta" . . . "9"^^ . . "RIV/00216224:14110/13:00065644" . . "RIV/00216224:14110/13:00065644!RIV14-MZ0-14110___" . . . .