. "0862-495X" . . . "CZ - \u010Cesk\u00E1 republika" . "6"^^ . "H\u00E1jek, Roman" . . . . "Pot\u00E1\u010Dov\u00E1, Anna" . "P(NT11154), P(NT12130), P(NT13190), P(NT14575)" . "V\u0161echny intracelul\u00E1rn\u00ED a n\u011Bkter\u00E9 extracelul\u00E1rn\u00ED proteiny jsou kontinu\u00E1ln\u011B degradov\u00E1ny a nahrazov\u00E1ny synt\u00E9zou nov\u00FDch protein\u016F. Oba tyto d\u011Bje musej\u00ED z\u016Fstat ve vz\u00E1jemn\u00E9 rovnov\u00E1ze, nebo\u0165j ej\u00ED naru\u0161en\u00ED by mohlo v\u00E9st ke vzniku z\u00E1va\u017En\u00FDch onemocn\u011Bn\u00ED. Bu\u0148ky obsahuj\u00ED mnoho proteolytick\u00FDch syst\u00E9m\u016F, kter\u00E9 zaji\u0161\u0165uj\u00ED vysoce specifickou a kontrolovanou degradaci protein\u016F. Jedn\u00EDm z nich je proteazom, slo\u017Eit\u00FD molekul\u00E1rn\u00ED stroj slou\u017E\u00EDc\u00ED k degradaci protein\u016F konjugovan\u00FDch s ubikvitinem. Od prvn\u00ED izolace proteazomu v roce 1968 bylo objeveno mnoho detail\u016F o fungov\u00E1n\u00ED tohoto syst\u00E9mu. V roce 2004 byla za tyto objevy dokonce ud\u011Blena Nobelova cena za chemii. V na\u0161\u00ED p\u0159ehledov\u00E9 pr\u00E1ci jsme se zam\u011B\u0159ili na shrnut\u00ED dosavadn\u00EDch poznatk\u016F o mechanizmech vysoce selektivn\u00ED degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou. Jednotliv\u00E9 kapitoly tohoto \u010Dl\u00E1nku pojedn\u00E1vaj\u00ED o struktu\u0159e a funkci syst\u00E9mu ubikvitin-proteazom, mechanizmech regulace degradace protein\u016F a biologick\u00FDch \u00FA\u010Dinc\u00EDch inhibitor\u016F proteazomu."@cs . "26" . . "Degradation of proteins by ubiquitin-proteasome pathway"@en . . "68203" . "Degradation of proteins by ubiquitin-proteasome pathway"@en . . . . . . "4" . . . "All intracellular and some extracellular proteins are continually degraded and replaced by synthesis of new proteins. Both these processes need to stay in equilibrium since their balance may lead to emergence of diseases. Cells contain many proteolytic systems that ensure highly specific and controlled degradation of proteins. One of these systems is the proteasome, a very complex molecular engine allowing degradation of proteins conjugated to ubiquitin. Since the first isolation of proteasome in 1968, many details about its function have been uncovered. In 2004, Nobel Prize for chemistry was awarded for these discoveries. In our review article, we aimed to summarize information about the mechanism of highly selective degradation of proteins by the ubiquitin-proteasome pathway."@en . "V\u0161echny intracelul\u00E1rn\u00ED a n\u011Bkter\u00E9 extracelul\u00E1rn\u00ED proteiny jsou kontinu\u00E1ln\u011B degradov\u00E1ny a nahrazov\u00E1ny synt\u00E9zou nov\u00FDch protein\u016F. Oba tyto d\u011Bje musej\u00ED z\u016Fstat ve vz\u00E1jemn\u00E9 rovnov\u00E1ze, nebo\u0165j ej\u00ED naru\u0161en\u00ED by mohlo v\u00E9st ke vzniku z\u00E1va\u017En\u00FDch onemocn\u011Bn\u00ED. Bu\u0148ky obsahuj\u00ED mnoho proteolytick\u00FDch syst\u00E9m\u016F, kter\u00E9 zaji\u0161\u0165uj\u00ED vysoce specifickou a kontrolovanou degradaci protein\u016F. Jedn\u00EDm z nich je proteazom, slo\u017Eit\u00FD molekul\u00E1rn\u00ED stroj slou\u017E\u00EDc\u00ED k degradaci protein\u016F konjugovan\u00FDch s ubikvitinem. Od prvn\u00ED izolace proteazomu v roce 1968 bylo objeveno mnoho detail\u016F o fungov\u00E1n\u00ED tohoto syst\u00E9mu. V roce 2004 byla za tyto objevy dokonce ud\u011Blena Nobelova cena za chemii. V na\u0161\u00ED p\u0159ehledov\u00E9 pr\u00E1ci jsme se zam\u011B\u0159ili na shrnut\u00ED dosavadn\u00EDch poznatk\u016F o mechanizmech vysoce selektivn\u00ED degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou. Jednotliv\u00E9 kapitoly tohoto \u010Dl\u00E1nku pojedn\u00E1vaj\u00ED o struktu\u0159e a funkci syst\u00E9mu ubikvitin-proteazom, mechanizmech regulace degradace protein\u016F a biologick\u00FDch \u00FA\u010Dinc\u00EDch inhibitor\u016F proteazomu." . . "Klinick\u00E1 onkologie" . "Degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou"@cs . "Kubiczkov\u00E1, Lenka" . "Degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou" . "\u0160ev\u010D\u00EDkov\u00E1, Sabina" . . . . "RIV/00216224:14110/13:00065640" . "RIV/00216224:14110/13:00065640!RIV14-MZ0-14110___" . "14110" . . "Degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou"@cs . . "Sedla\u0159\u00EDkov\u00E1, Lenka" . . "Degradace protein\u016F ubikvitin-proteazomovou dr\u00E1hou" . "NF-kappa B; Proteasome; Proteasome inhibitors; Protein degradation; Ubiquitin"@en . "Mat\u011Bj\u00EDkov\u00E1, Jana" . . . "6"^^ . . . "[DF6CA879CBC6]" . "6"^^ .