"H\u00E1jek, Roman" . "Molecular heterogeneity and centrosome-associated genes in multiple myeloma"@en . . . "9" . . "P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190)" . "1042-8194" . "Kryukov, Fedor" . . . "9"^^ . . . "Molecular heterogeneity and centrosome-associated genes in multiple myeloma" . . . "In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis."@en . . . "[D34D8773EFBB]" . "Jarkovsk\u00FD, Ji\u0159\u00ED" . "Multiple myeloma; centrosome abnormalities; gene expression profile"@en . "10.3109/10428194.2013.764416" . . "000323492400022" . . "14110" . . . . "7"^^ . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "89312" . "Kugl\u00EDk, Petr" . "Molecular heterogeneity and centrosome-associated genes in multiple myeloma" . "\u0160ev\u010D\u00EDkov\u00E1, Sabina" . "Budinsk\u00E1, Eva" . "RIV/00216224:14110/13:00065610!RIV14-MZ0-14110___" . "RIV/00216224:14110/13:00065610" . . "Leukemia & Lymphoma" . . "Ihnatov\u00E1, Ivana" . . . . "Dementyeva, Elena" . . "In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis." . "N\u011Bmec, Pavel" . . "54" . . . "10"^^ . "Dementyeva, Elena" . "Molecular heterogeneity and centrosome-associated genes in multiple myeloma"@en . . "Kubiczkov\u00E1, Lenka" .