. . . . "Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or backround microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined."@en . "K\u0159en, Leo\u0161" . "Multifunk\u010Dn\u00ED imunomodula\u010Dn\u00ED proteiny HLA-E a HLA-G v klasick\u00E9m Hodgkinov\u011B lymfomu: potenci\u00E1ln\u00ED v\u00FDznam." . "Masaryk\u016Fv onkologick\u00FD \u00FAstav v Brn\u011B p\u0159i p\u0159\u00EDle\u017Eitosti kon\u00E1n\u00ED XXXVI. Brn\u011Bnsk\u00FDch onkologick\u00FDch dn\u016F a XXVI. Konference pro nel\u00E9ka\u0159sk\u00E9 zdravotnick\u00E9 pracovn\u00EDky v roce 2012" . "Kr\u00E1l, Zden\u011Bk" . . "Brno" . "Fabian, Pavel" . . "Eduka\u010Dn\u00ED sborn\u00EDk- XXXVI. Brn\u011Bnsk\u00FDch onkologick\u00FDch dn\u016F a XXVI. Konference pro nel\u00E9ka\u0159sk\u00E9 zdravotnick\u00E9 pracovn\u00EDky" . "Brno" . "[7190F6112654]" . "3"^^ . "RIV/00216224:14110/12:00063896" . "Mich\u00E1lek, Jaroslav" . "Multifunk\u010Dn\u00ED imunomodula\u010Dn\u00ED proteiny HLA-E a HLA-G v klasick\u00E9m Hodgkinov\u011B lymfomu: potenci\u00E1ln\u00ED v\u00FDznam."@cs . "Slab\u00FD, Ond\u0159ej" . . . . "9"^^ . . . . . "152352" . . . "7"^^ . "Multifunk\u010Dn\u00ED imunomodula\u010Dn\u00ED proteiny HLA-E a HLA-G v klasick\u00E9m Hodgkinov\u011B lymfomu: potenci\u00E1ln\u00ED v\u00FDznam." . . "Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications."@en . "Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications."@en . "Hodgkin\u016Fv lymfom je ozna\u010Den\u00ED pro dv\u011B samostatn\u00E9 n\u00E1dorov\u00E9 entity: nodul\u00E1rn\u00ED Hodgkin\u016Fv lymfom s p\u0159evahou (predominanc\u00ED) lymfocyt\u016F a klasick\u00FD Hodgkin\u016Fv lymfom (s podtypy nodul\u00E1rn\u00ED skler\u00F3za, sm\u00ED\u0161en\u00E1 bun\u011B\u010Dnost, bohat\u00FD na lymfocyty a chud\u00FD na lymfocyty). Nodul\u00E1rn\u00ED Hodgkin\u016Fv lymfom s p\u0159evahou (predominanc\u00ED) lymfocyt\u016F je B lymfoproliferace charakterizovan\u00E1 nodul\u00E1rn\u00ED \u010Di nodul\u00E1rn\u00ED a dif\u00FAzn\u00ED proliferac\u00ED roztrou\u0161en\u00FDch velk\u00FDch neoplastick\u00FDch bun\u011Bk se zproh\u00FDban\u00FDmi lalo\u010Dnat\u00FDmi j\u00E1dry, kter\u00E9 se ozna\u010Duj\u00ED jako \u201Cpopcorn\u201C \u010Di LP bu\u0148ky (lymphocyte predominant, d\u0159\u00EDve rovn\u011B\u017E lymfohistiocyt\u00E1rn\u00ED bu\u0148ky, L&H bu\u0148ky). Tyto bu\u0148ky jev\u00ED pozitivitu na B markery (CD 20) a jsou negativn\u00ED na CD 30 a negativn\u00ED na CD 15. V pozad\u00ED je sm\u00ED\u0161en\u011B reaktivn\u00ED celulizace s p\u0159evahou mal\u00FDch lymfocyt\u016F B linie. Klasick\u00FD Hodgkin\u016Fv lymfom je lymfoproliferace ve v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F B linie, charakterizovan\u00E1 tzv." . . . "K\u0159enov\u00E1, Zdenka" . "Multifunk\u010Dn\u00ED imunomodula\u010Dn\u00ED proteiny HLA-E a HLA-G v klasick\u00E9m Hodgkinov\u011B lymfomu: potenci\u00E1ln\u00ED v\u00FDznam."@cs . "Hodgkin\u016Fv lymfom je ozna\u010Den\u00ED pro dv\u011B samostatn\u00E9 n\u00E1dorov\u00E9 entity: nodul\u00E1rn\u00ED Hodgkin\u016Fv lymfom s p\u0159evahou (predominanc\u00ED) lymfocyt\u016F a klasick\u00FD Hodgkin\u016Fv lymfom (s podtypy nodul\u00E1rn\u00ED skler\u00F3za, sm\u00ED\u0161en\u00E1 bun\u011B\u010Dnost, bohat\u00FD na lymfocyty a chud\u00FD na lymfocyty). Nodul\u00E1rn\u00ED Hodgkin\u016Fv lymfom s p\u0159evahou (predominanc\u00ED) lymfocyt\u016F je B lymfoproliferace charakterizovan\u00E1 nodul\u00E1rn\u00ED \u010Di nodul\u00E1rn\u00ED a dif\u00FAzn\u00ED proliferac\u00ED roztrou\u0161en\u00FDch velk\u00FDch neoplastick\u00FDch bun\u011Bk se zproh\u00FDban\u00FDmi lalo\u010Dnat\u00FDmi j\u00E1dry, kter\u00E9 se ozna\u010Duj\u00ED jako \u201Cpopcorn\u201C \u010Di LP bu\u0148ky (lymphocyte predominant, d\u0159\u00EDve rovn\u011B\u017E lymfohistiocyt\u00E1rn\u00ED bu\u0148ky, L&H bu\u0148ky). Tyto bu\u0148ky jev\u00ED pozitivitu na B markery (CD 20) a jsou negativn\u00ED na CD 30 a negativn\u00ED na CD 15. V pozad\u00ED je sm\u00ED\u0161en\u011B reaktivn\u00ED celulizace s p\u0159evahou mal\u00FDch lymfocyt\u016F B linie. Klasick\u00FD Hodgkin\u016Fv lymfom je lymfoproliferace ve v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F B linie, charakterizovan\u00E1 tzv."@cs . "14110" . . . "2012-01-01+01:00"^^ . "Jan\u00EDkov\u00E1, Andrea" . "I" . "9788086793238" . "Hodgkin's lymphoma; lymphoproliferative disease; HLA-G; HLA-E"@en . "Sou\u010Dek, Ond\u0159ej" . . . "\u0160t\u011Brba, Jaroslav" . "RIV/00216224:14110/12:00063896!RIV13-MSM-14110___" . .