"Auto\u0159i popisuj\u00ED p\u0159\u00EDpad 59 let\u00E9 \u017Eeny, u kter\u00E9 byla transplantace jater provedena pro sekund\u00E1rn\u00ED bili\u00E1rn\u00ED cirh\u00F3zu po iatrogenn\u00EDm po\u0161kozen\u00ED ductus choledochus. U pacientky se rozvinul ko\u017En\u00ED exant\u00E9m prov\u00E1zen\u00FD pr\u016Fjmy s n\u00E1slednou leukopeni\u00ED a rozvojem septick\u00E9ho \u0161oku. Diagn\u00F3za GVHD byla ov\u011B\u0159ena ko\u017En\u00ED biopsi\u00ED a podpo\u0159ena stanoven\u00EDm chimerizmu. V l\u00E9\u010Db\u011B byly pou\u017Eity vysok\u00E9 d\u00E1vky glukokortikoid\u016F, udr\u017Eov\u00E1n\u00ED co nejni\u017E\u0161\u00EDch \u00FA\u010Dinn\u00FDch hladin tacrolimu, pod\u00E1n\u00ED imunoglobulin\u016F, anti-CD 25 mAbs, symptomatick\u00E1 terapie (faktor stimuluj\u00EDc\u00ED granulocyty, antibiotika, antivirotika). Nyn\u00ED, 10 m\u011Bs\u00EDc\u016F po transplantaci jater, je pacientka bez klinick\u00FDch zn\u00E1mek GVHD s dobrou funkc\u00ED jatern\u00EDho \u0161t\u011Bpu."@cs . "7"^^ . "Gastroenterologie a hepatologie" . "8"^^ . "Graft vs host disease jako neobvykl\u00E1 komplikace po transplantaci jater"@cs . . "Jedli\u010Dkov\u00E1, Hana" . "Graft vs host disease jako neobvykl\u00E1 komplikace po transplantaci jater"@cs . "The autors describe the case of a 59-year-old woman who underwent liver transplant due to secondary biliary cirrhosis following iatrogenic damage of the ductus choledochus. The patient developed skin exanthem accompanied by diarrhoea, followed by leukopenia and septic shock. The GVHD diagnosis was established by skin biopsy and supported by determining the chimerism. The treatment involved high doses of glucocorticoids maintaining the lowest possible effective levels of tacrolimus, immunoglobulins, anti-CD25 mAbs, and symptomatic therapy (factor stimulating granulocytes, antibiotics and antivirotics). The patient is now 10 months after the liver transplant without any GVHD clinical symptoms and with good functioning of the liver graft."@en . . . "exanthem; graft-versus-host disease; liver transplant"@en . . "Graft vs host disease jako neobvykl\u00E1 komplikace po transplantaci jater" . "Graft-versus-host disease as an unusual complication following liver transplant"@en . "RIV/00216224:14110/12:00063801!RIV13-MSM-14110___" . . . . "14110" . "2"^^ . . "Kuman, Milan" . "2" . . "N\u011Bmec, Petr" . . . . "66" . "RIV/00216224:14110/12:00063801" . . "Auto\u0159i popisuj\u00ED p\u0159\u00EDpad 59 let\u00E9 \u017Eeny, u kter\u00E9 byla transplantace jater provedena pro sekund\u00E1rn\u00ED bili\u00E1rn\u00ED cirh\u00F3zu po iatrogenn\u00EDm po\u0161kozen\u00ED ductus choledochus. U pacientky se rozvinul ko\u017En\u00ED exant\u00E9m prov\u00E1zen\u00FD pr\u016Fjmy s n\u00E1slednou leukopeni\u00ED a rozvojem septick\u00E9ho \u0161oku. Diagn\u00F3za GVHD byla ov\u011B\u0159ena ko\u017En\u00ED biopsi\u00ED a podpo\u0159ena stanoven\u00EDm chimerizmu. V l\u00E9\u010Db\u011B byly pou\u017Eity vysok\u00E9 d\u00E1vky glukokortikoid\u016F, udr\u017Eov\u00E1n\u00ED co nejni\u017E\u0161\u00EDch \u00FA\u010Dinn\u00FDch hladin tacrolimu, pod\u00E1n\u00ED imunoglobulin\u016F, anti-CD 25 mAbs, symptomatick\u00E1 terapie (faktor stimuluj\u00EDc\u00ED granulocyty, antibiotika, antivirotika). Nyn\u00ED, 10 m\u011Bs\u00EDc\u016F po transplantaci jater, je pacientka bez klinick\u00FDch zn\u00E1mek GVHD s dobrou funkc\u00ED jatern\u00EDho \u0161t\u011Bpu." . "Ost\u0159\u00ED\u017Eek, Tom\u00E1\u0161" . . "\u017Dampachov\u00E1, V\u00EDta" . "Graft vs host disease jako neobvykl\u00E1 komplikace po transplantaci jater" . "I" . "CZ - \u010Cesk\u00E1 republika" . . "Mejzl\u00EDk, Vladim\u00EDr" . "1804-7874" . "[0B81CC73A34D]" . "Husov\u00E1, Libu\u0161e" . . "Graft-versus-host disease as an unusual complication following liver transplant"@en . "\u0160t\u011Bp\u00E1nkov\u00E1, So\u0148a" . "138369" .