. . "Kortikotropin-releasing hormon a adrenokortikotropn\u00ED hormon \u2013 mo\u017En\u00E9 markery n\u011Bkter\u00FDch t\u011Bhotensk\u00FDch patologi\u00ED"@cs . . . "Kortikotropin-releasing hormon a adrenokortikotropn\u00ED hormon \u2013 mo\u017En\u00E9 markery n\u011Bkter\u00FDch t\u011Bhotensk\u00FDch patologi\u00ED" . "RIV/00216224:14110/12:00060424!RIV13-MSM-14110___" . "adrenocorticotropin hormone; corticotropin-releasing hormone; pregnancy; preeclampsia; uteroplacental insufficiency"@en . "Va\u0161k\u016F, Anna" . "Adrenocorticotropin hormone (ACTH) is produced from the anterior pituitary gland and can be considered as one of the main elements of the hypothalamic-pituitary-adrenal axis. ACTH secretion is controled by corticotropin-releasing hormone (CRH) from hypothalamus. ACTH stimulates the adrenal cortex. It\u2019s affects synthesis and releasing of glucocorticoids, precursors of aldosterone, which affects the synthesis of mineralocorticoids. Preeclampsia and intrauterine growth retardation (IUGR) is one of the major pregnancy pathologies. The aetiology of these states are not clearly known, it is assumed that factors pathogenetic chain has been operating in early pregnancy. These factors are generally similar for both diseases. It is assumed that these pathologies will activate the hypothalamic-pituitary-adrenal stress axis both for mother and fetus. In research studies, mathernal plasma CRH concentrations are elevated in complicated pregnancies."@en . . . "RIV/00216224:14110/12:00060424" . . "[E136278E2B80]" . "2" . . "Hodick\u00E1, Zuzana" . . "Kortikotropin-releasing hormon a adrenokortikotropn\u00ED hormon \u2013 mo\u017En\u00E9 markery n\u011Bkter\u00FDch t\u011Bhotensk\u00FDch patologi\u00ED" . . "1210-7832" . "Adrenokortikotropn\u00ED hormon (ACTH) je produkov\u00E1n z p\u0159edn\u00EDho laloku hypof\u00FDzy a m\u016F\u017Eeme jej pova\u017Eovat za jeden z hlavn\u00EDch element\u016F hypotalamo-hypofyz\u00E1rn\u011B-adren\u00E1ln\u00ED osy. Sekrece ACTH podl\u00E9h\u00E1 \u0159\u00EDzen\u00ED kortikotropn\u00EDho-releasing hormonu (CRH) z hypotalamu. CRH je siln\u00FD vazodilat\u00E1tor a v\u00FDznamn\u011B se pod\u00EDl\u00ED na regulaci produkce prostaglandin\u016F a sekreci ACTH. ACTH stimuluje k\u016Fru nadledvin, t\u00EDm synt\u00E9zu a v\u00FDdej glukokortikoid\u016F, pod\u00EDl\u00ED se d\u00E1le na stimulaci prekurzor\u016F aldosteronu, \u010D\u00EDm\u017E ovliv\u0148uje synt\u00E9zu mineralokortikoid\u016F a m\u00E1 i dal\u0161\u00ED metabolick\u00E9 \u00FA\u010Dinky. Preeklampsie a intrauterinn\u00ED r\u016Fstov\u00E1 retardace (IUGR) jsou jedny z nejz\u00E1va\u017En\u011Bj\u0161\u00EDch t\u011Bhotensk\u00FDch patologi\u00ED. Etiologie t\u011Bchto stav\u016F nen\u00ED jednozna\u010Dn\u011B zn\u00E1m\u00E1, p\u0159edpokl\u00E1d\u00E1 se, \u017Ee faktory patogenetick\u00E9ho \u0159et\u011Bzce p\u016Fsob\u00ED ji\u017E v \u010Dasn\u00E9m t\u011Bhotenstv\u00ED a jsou obecn\u011B podobn\u00E9 pro ob\u011B dv\u011B onemocn\u011Bn\u00ED; d\u00E1 se o\u010Dek\u00E1vat, \u017Ee p\u0159i t\u011Bchto stavech bude jak u matky, tak u plodu doch\u00E1zet ke zv\u00FD\u0161en\u00E9 aktivaci hypotalamo-hypofyz\u00E1rn\u011B-adren\u00E1ln\u00ED stresov\u00E9 osy." . "Bienertov\u00E1 Va\u0161k\u016F, Julie" . . . . "I" . . "Adrenocorticotropin hormone \u2013 possible marker of pregnancy pathologies"@en . "145671" . "77" . . "Kortikotropin-releasing hormon a adrenokortikotropn\u00ED hormon \u2013 mo\u017En\u00E9 markery n\u011Bkter\u00FDch t\u011Bhotensk\u00FDch patologi\u00ED"@cs . "Adrenokortikotropn\u00ED hormon (ACTH) je produkov\u00E1n z p\u0159edn\u00EDho laloku hypof\u00FDzy a m\u016F\u017Eeme jej pova\u017Eovat za jeden z hlavn\u00EDch element\u016F hypotalamo-hypofyz\u00E1rn\u011B-adren\u00E1ln\u00ED osy. Sekrece ACTH podl\u00E9h\u00E1 \u0159\u00EDzen\u00ED kortikotropn\u00EDho-releasing hormonu (CRH) z hypotalamu. CRH je siln\u00FD vazodilat\u00E1tor a v\u00FDznamn\u011B se pod\u00EDl\u00ED na regulaci produkce prostaglandin\u016F a sekreci ACTH. ACTH stimuluje k\u016Fru nadledvin, t\u00EDm synt\u00E9zu a v\u00FDdej glukokortikoid\u016F, pod\u00EDl\u00ED se d\u00E1le na stimulaci prekurzor\u016F aldosteronu, \u010D\u00EDm\u017E ovliv\u0148uje synt\u00E9zu mineralokortikoid\u016F a m\u00E1 i dal\u0161\u00ED metabolick\u00E9 \u00FA\u010Dinky. Preeklampsie a intrauterinn\u00ED r\u016Fstov\u00E1 retardace (IUGR) jsou jedny z nejz\u00E1va\u017En\u011Bj\u0161\u00EDch t\u011Bhotensk\u00FDch patologi\u00ED. Etiologie t\u011Bchto stav\u016F nen\u00ED jednozna\u010Dn\u011B zn\u00E1m\u00E1, p\u0159edpokl\u00E1d\u00E1 se, \u017Ee faktory patogenetick\u00E9ho \u0159et\u011Bzce p\u016Fsob\u00ED ji\u017E v \u010Dasn\u00E9m t\u011Bhotenstv\u00ED a jsou obecn\u011B podobn\u00E9 pro ob\u011B dv\u011B onemocn\u011Bn\u00ED; d\u00E1 se o\u010Dek\u00E1vat, \u017Ee p\u0159i t\u011Bchto stavech bude jak u matky, tak u plodu doch\u00E1zet ke zv\u00FD\u0161en\u00E9 aktivaci hypotalamo-hypofyz\u00E1rn\u011B-adren\u00E1ln\u00ED stresov\u00E9 osy."@cs . "3"^^ . . "4"^^ . . "Adrenocorticotropin hormone \u2013 possible marker of pregnancy pathologies"@en . "4"^^ . "Ventruba, Pavel" . "\u010Cesk\u00E1 gynekologie" . . "14110" . . "CZ - \u010Cesk\u00E1 republika" . .