"10"^^ . "RIV/00216224:14110/12:00060418" . "14110" . "Kladribin je velmi \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk a vz\u00E1cn\u00FDch histiocyt\u00E1rn\u00EDch nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu"@cs . "Zahradov\u00E1, Lenka" . "CZ - \u010Cesk\u00E1 republika" . "9"^^ . . "Kladribin je velmi \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk a vz\u00E1cn\u00FDch histiocyt\u00E1rn\u00EDch nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu" . . . . "P(NT11154), P(NT12130), P(NT12215), S, Z(MSM0021622434)" . "11"^^ . "Szturz, Petr" . "Pour, Lud\u011Bk" . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "Kladribin (2-chlorodeoxyadenosin) je v bu\u0148ce metabolizov\u00E1n a fosforylov\u00E1n a\u017E na 2-chloroadenosintrifosf\u00E1t, kter\u00FD je vlastn\u00ED \u00FA\u010Dinnou formou l\u00E9ku. Akumulace 2-chloroadenosintrifosf\u00E1tu je nejv\u011Bt\u0161\u00ED v bu\u0148k\u00E1ch, jejich\u017E aktiva\u010Dn\u00ED (fosforyla\u010Dn\u00ED) enzym, deoxycytidinkin\u00E1za, m\u00E1 nejv\u011Bt\u0161\u00ED aktivitu, zat\u00EDmco inaktiva\u010Dn\u00ED (defosforyla\u010Dn\u00ED) enzym, cytoplazmatick\u00E1 5-nukleotid\u00E1za, m\u00E1 nejmen\u0161\u00ED aktivitu. Velmi p\u0159\u00EDzniv\u00FD pom\u011Br uveden\u00FDch 2 enzym\u016F pro vysokou \u00FA\u010Dinnost kladribinu je v klidov\u00FDch a proliferuj\u00EDc\u00EDch lymfocytech. Proto je kladribin \u00FA\u010Dinn\u00FDm l\u00E9kem pro pacienty s vlasatobun\u011B\u010Dnou leukemi\u00ED, Waldenstr\u00F6movou makroglobulinemi\u00ED, ale i chronickou B-lymfocyt\u00E1rn\u00ED leukemi\u00ED. Podobn\u011B vysok\u00E9 koncentrace 2-chloroadenosintrifosf\u00E1tu jsou v\u0161ak dosahov\u00E1ny v n\u011Bkter\u00FDch bu\u0148k\u00E1ch histiocyt\u00E1rn\u00ED \u0159ady, v monocytech a tak\u00E9 v Langerhansov\u00FDch dendritick\u00FDch bu\u0148k\u00E1ch. Proto je kladribin vysoce \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk (LCH) a tak\u00E9 pro l\u00E9\u010Dbu nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu."@cs . . . "Cladribine is highly effective in the treatment of Langerhans cell histiocytosis and rare histiocytic disorders of the juvenile xanthogranuloma group"@en . "Cladribine is highly effective in the treatment of Langerhans cell histiocytosis and rare histiocytic disorders of the juvenile xanthogranuloma group"@en . . . . "Kladribin je velmi \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk a vz\u00E1cn\u00FDch histiocyt\u00E1rn\u00EDch nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu"@cs . . . . . . "Mayer, Ji\u0159\u00ED" . . . . . . . "Kladribin je velmi \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk a vz\u00E1cn\u00FDch histiocyt\u00E1rn\u00EDch nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu" . "cladribine; 2-chlorodeoxyadenosine; Langerhans cell histiocytosis; diabetes insipidus; juvenile xanthogranuloma; plane xanthoma; Erdheim-Chester disease; Rosai-Dorfman disease; sinus histiocytosis with massive lymphadenopathy"@en . . "0042-773X" . . "Kr\u00E1l, Zden\u011Bk" . . "Tom\u00ED\u0161ka, Miroslav" . . . . . . . "[78EBEFFADA7A]" . "6" . "\u0158eh\u00E1k, Zden\u011Bk" . . "Adam, Zden\u011Bk" . . "58" . . "RIV/00216224:14110/12:00060418!RIV13-MZ0-14110___" . "144686" . . "Krej\u010D\u00ED, Marta" . "Koukalov\u00E1, R." . "Kladribin (2-chlorodeoxyadenosin) je v bu\u0148ce metabolizov\u00E1n a fosforylov\u00E1n a\u017E na 2-chloroadenosintrifosf\u00E1t, kter\u00FD je vlastn\u00ED \u00FA\u010Dinnou formou l\u00E9ku. Akumulace 2-chloroadenosintrifosf\u00E1tu je nejv\u011Bt\u0161\u00ED v bu\u0148k\u00E1ch, jejich\u017E aktiva\u010Dn\u00ED (fosforyla\u010Dn\u00ED) enzym, deoxycytidinkin\u00E1za, m\u00E1 nejv\u011Bt\u0161\u00ED aktivitu, zat\u00EDmco inaktiva\u010Dn\u00ED (defosforyla\u010Dn\u00ED) enzym, cytoplazmatick\u00E1 5-nukleotid\u00E1za, m\u00E1 nejmen\u0161\u00ED aktivitu. Velmi p\u0159\u00EDzniv\u00FD pom\u011Br uveden\u00FDch 2 enzym\u016F pro vysokou \u00FA\u010Dinnost kladribinu je v klidov\u00FDch a proliferuj\u00EDc\u00EDch lymfocytech. Proto je kladribin \u00FA\u010Dinn\u00FDm l\u00E9kem pro pacienty s vlasatobun\u011B\u010Dnou leukemi\u00ED, Waldenstr\u00F6movou makroglobulinemi\u00ED, ale i chronickou B-lymfocyt\u00E1rn\u00ED leukemi\u00ED. Podobn\u011B vysok\u00E9 koncentrace 2-chloroadenosintrifosf\u00E1tu jsou v\u0161ak dosahov\u00E1ny v n\u011Bkter\u00FDch bu\u0148k\u00E1ch histiocyt\u00E1rn\u00ED \u0159ady, v monocytech a tak\u00E9 v Langerhansov\u00FDch dendritick\u00FDch bu\u0148k\u00E1ch. Proto je kladribin vysoce \u00FA\u010Dinn\u00FDm l\u00E9kem pro l\u00E9\u010Dbu histiocyt\u00F3zy z Langerhansov\u00FDch bun\u011Bk (LCH) a tak\u00E9 pro l\u00E9\u010Dbu nemoc\u00ED ze skupiny juveniln\u00EDho xantogranulomu." . . "Cladribine (2-chlorodeoxyadenosine) is metabolised and phosphorylated in a cell up to 2-chloroadenosine triphosphate which is the actual effective form of the drug. The greatest accumulation of 2-chloroadenosine triphosphate is in the most active cells, where activating (phosphorylation) enzyme, deoxycytidine kinase, has the highest activity, whereas inactivating enzyme (dephosphorylation), cytoplasmic 5-nucleotidase, has the lowest activity. A very good ratio of the both enzymes for high effectiveness of cladribine is in resting and proliferating lymphocytes. Therefore, cladribine is an effective medication for hairy cell leukemia, Waldenstr\u00F6m macroglobulinemia but also for chronic B- lymphocytic leukemia. However, such high concentrations of 2-chloroadenosine triphosphate are reached in some cells of histiocytic lines, in monocytes and also in Langerhans dendritic cells."@en .