"9"^^ . "\u0160laisov\u00E1, Radka" . . "Moulis, Mojm\u00EDr" . . . "0862-495X" . "24" . "H\u00E1jek, Roman" . "Szturz, Petr" . . "7"^^ . . "189278" . "Castlemanova choroba je vz\u00E1cn\u00E9 neklon\u00E1ln\u00ED lymfoproliferativn\u00ED onemocn\u011Bn\u00ED s dosud ne zcela jasnou etiopatogenez\u00ED. Klinicky rozli\u0161ujeme unicentrickou (lokalizovanou) a multicentrickou (generalizovanou) formu, histopatologicky pak hyalinn\u011B-vaskul\u00E1rn\u00ED, plazmocelul\u00E1rn\u00ED a sm\u00ED\u0161enou variantu nemoci. Tyto typy se navz\u00E1jem li\u0161\u00ED nejen klinick\u00FDm pr\u016Fb\u011Bhem onemocn\u011Bn\u00ED, ale p\u0159edev\u0161\u00EDm zp\u016Fsobem l\u00E9\u010Debn\u00E9ho ovlivn\u011Bn\u00ED. Zat\u00EDmco unicentrick\u00E1 hyalinn\u011B- vaskul\u00E1rn\u00ED forma se obvykle manifestuje ve form\u011B benign\u00EDho zv\u011Bt\u0161ov\u00E1n\u00ED lymfatick\u00E9 uzliny a kompletn\u00ED chirurgick\u00E1 excize dosahuje 100 % l\u00E9\u010Debn\u00FDch odpov\u011Bd\u00ED, tak multicentrick\u00E1 plazmocelul\u00E1rn\u00ED varianta je agresivn\u00ED choroba s celkov\u00FDmi p\u0159\u00EDznaky, laboratorn\u00EDmi odchylkami a nutnost\u00ED syst\u00E9mov\u00E9 l\u00E9\u010Dby. C\u00EDl: Tato pr\u00E1ce p\u0159in\u00E1\u0161\u00ED p\u0159ehled informac\u00ED o Castlemanov\u011B chorob\u011B od klinick\u00FDch a histopatologick\u00FDch znak\u016F nemoci a\u017E po mo\u017Enosti diagnostiky a l\u00E9\u010Dby." . . . . "Castlemanova choroba" . . "Adam, Zden\u011Bk" . . . . . "Castlemanova choroba je vz\u00E1cn\u00E9 neklon\u00E1ln\u00ED lymfoproliferativn\u00ED onemocn\u011Bn\u00ED s dosud ne zcela jasnou etiopatogenez\u00ED. Klinicky rozli\u0161ujeme unicentrickou (lokalizovanou) a multicentrickou (generalizovanou) formu, histopatologicky pak hyalinn\u011B-vaskul\u00E1rn\u00ED, plazmocelul\u00E1rn\u00ED a sm\u00ED\u0161enou variantu nemoci. Tyto typy se navz\u00E1jem li\u0161\u00ED nejen klinick\u00FDm pr\u016Fb\u011Bhem onemocn\u011Bn\u00ED, ale p\u0159edev\u0161\u00EDm zp\u016Fsobem l\u00E9\u010Debn\u00E9ho ovlivn\u011Bn\u00ED. Zat\u00EDmco unicentrick\u00E1 hyalinn\u011B- vaskul\u00E1rn\u00ED forma se obvykle manifestuje ve form\u011B benign\u00EDho zv\u011Bt\u0161ov\u00E1n\u00ED lymfatick\u00E9 uzliny a kompletn\u00ED chirurgick\u00E1 excize dosahuje 100 % l\u00E9\u010Debn\u00FDch odpov\u011Bd\u00ED, tak multicentrick\u00E1 plazmocelul\u00E1rn\u00ED varianta je agresivn\u00ED choroba s celkov\u00FDmi p\u0159\u00EDznaky, laboratorn\u00EDmi odchylkami a nutnost\u00ED syst\u00E9mov\u00E9 l\u00E9\u010Dby. C\u00EDl: Tato pr\u00E1ce p\u0159in\u00E1\u0161\u00ED p\u0159ehled informac\u00ED o Castlemanov\u011B chorob\u011B od klinick\u00FDch a histopatologick\u00FDch znak\u016F nemoci a\u017E po mo\u017Enosti diagnostiky a l\u00E9\u010Dby."@cs . "\u0158eh\u00E1k, Z." . . . "Castlemanova choroba" . . . . . "Koukalov\u00E1, R." . . . "Klinick\u00E1 onkologie" . . . "Castleman disease; lymphadenopathy; tocilizumab; interleukin; HHV-8; ultrasonography; computed tomography; PET scan"@en . "Castlemanova choroba"@cs . . . . . "RIV/00216224:14110/11:00054321!RIV12-MZ0-14110___" . . "[0B2D8023A20F]" . "Mayer, Ji\u0159\u00ED" . . "Volfov\u00E1, Pavl\u00EDna" . "RIV/00216224:14110/11:00054321" . . "Castleman disease is a rare non-clonal lymphoproliferative disorder with the etiopathogenesis not yet thoroughly clarified. Clinically, either unicentric (localized) or multicentric (generalized) forms are recognized while, histopathologically, hyaline-vascular, plasma-cell and mixed variants of the disease exist. These types vary one from another in their clinical courses and, importantly, in methods of therapeutic management. While the unicentric hyaline-vascular form usually manifests as benign growth of a single lymph node and treatment response to complete surgical excision reaches up to 100%, the multicentric plasmocellular variant is an aggressive disease with generalized symptoms, laboratory abnormalities and the need for systemic therapy. Aim: The paper provides an overview of information on Castleman disease from its clinical and histopathological signs to diagnostic and therapeutic options."@en . . . "Castleman Disease"@en . "11"^^ . "Castleman Disease"@en . "Castlemanova choroba"@cs . . "P(LC06027), P(NS10408), P(NT11154), P(NT12130), P(NT12215), Z(MSM0021622434), Z(MZ0MOU2005)" . "CZ - \u010Cesk\u00E1 republika" . . "6" . "14110" .