"Wourld Journal of Gastroenterology" . "F\u0151rstl, Miroslav" . "Kohoutov\u00E1, Darina" . "4"^^ . "000287627700008" . "187752" . "AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probiotics alone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestine were taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A, B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny."@en . "Kv\u011Btina, Jaroslav" . "9"^^ . . "13"^^ . "10.3748/wjg.v17.i5.609" . "\u0160marda, Jan" . "1007-9327" . "Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917" . "Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917"@en . . "\u0160majs, David" . "Rejchrt, Stanislav" . "Tachec\u00ED, Ilja" . "RIV/00216224:14110/11:00051585" . . . . . . . "Cyrany, Ji\u0159\u00ED" . . "Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917"@en . . . "Bure\u0161, Jan" . "[84AE270800DE]" . "14110" . "Kune\u0161, Martin" . "5" . . . "I, P(NS9665), Z(MSM0021622415), Z(MZ0FNHK2005)" . "Kop\u00E1\u010Dov\u00E1, Marcela" . "Vo\u0159\u00ED\u0161ek, Viktor" . . . "Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917" . . "CN - \u010C\u00EDnsk\u00E1 lidov\u00E1 republika" . . . "Bacteriocinogeny; Escherichia coli Nissle 1917; Experimental pigs; Indomethacin"@en . . . . "Lesn\u00E1, Ji\u0159ina" . "17" . . "RIV/00216224:14110/11:00051585!RIV12-MZ0-14110___" . . "AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probiotics alone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestine were taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A, B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny." . .