"nestin; plasma cells; multiple myeloma; myeloma stem cells; myeloma-initiating cells; flow cytometry"@en . . . "P(GAP304/10/1395), P(LC06027), P(NS10406), P(NS10408), P(NT11154), Z(MSM0021622434)" . . . . . "Klinick\u00E1 onkologie" . "[A1EB555DD14C]" . "Impact of Nestin Analysis in Multiple Myeloma" . . . . . . "Impact of Nestin Analysis in Multiple Myeloma" . . "Nestin, a marker of multipotent precursor cells, is an important dynamic structure; its polymerization/ depolymerization influences intracellular signaling and participates in key cell processes such as proliferation, migration and cell survival. It is presumed that nestin plays a central role in carcinogenesis. It is suggested that nestin might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells. Unexpectedly, nestin has been identified in mature CD138+CD38+ plasma cells (PC) of multiple myeloma patients (MM). Expression of nestin, a marker of stem/progenitor cells, in malignant PC, that are considered to be terminally differentiated, indicates that nestin might play a unique role in pathology of MM." . "24" . "Barto\u0148ov\u00E1, Jana" . . "\u0160v\u00E1chov\u00E1, Hana" . . "CZ - \u010Cesk\u00E1 republika" . . . "\u0158\u00EDhov\u00E1, Lucie" . "RIV/00216224:14110/11:00049845" . . . "Impact of Nestin Analysis in Multiple Myeloma"@en . . "Nestin, a marker of multipotent precursor cells, is an important dynamic structure; its polymerization/ depolymerization influences intracellular signaling and participates in key cell processes such as proliferation, migration and cell survival. It is presumed that nestin plays a central role in carcinogenesis. It is suggested that nestin might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells. Unexpectedly, nestin has been identified in mature CD138+CD38+ plasma cells (PC) of multiple myeloma patients (MM). Expression of nestin, a marker of stem/progenitor cells, in malignant PC, that are considered to be terminally differentiated, indicates that nestin might play a unique role in pathology of MM."@en . . . "5"^^ . "6"^^ . . "H\u00E1jek, Roman" . "RIV/00216224:14110/11:00049845!RIV12-MZ0-14110___" . "203694" . . . . "Suppl." . "Pour, Lud\u011Bk" . . "5"^^ . "14110" . "Impact of Nestin Analysis in Multiple Myeloma"@en . . . "Pot\u00E1\u010Dov\u00E1, Anna" . "0862-495X" . .