. "IgA pemphigus a monoklon\u00E1ln\u00ED gamapatie, je zde souvislost ?" . . . "Va\u0161k\u016F, Vladim\u00EDr" . . . "[41DDAE50F488]" . . "3"^^ . "4" . "4" . . . "262814" . . . . "IgA pemphigus a monoklon\u00E1ln\u00ED gamapatie, je zde souvislost ?"@cs . . "P(LC06027), Z(MSM0021622434)" . . . "IgA pemphigus and monoclonal gammopathy, is there a connection ?"@en . . "Mayer, Ji\u0159\u00ED" . "IgA pemphigus a monoklon\u00E1ln\u00ED gamapatie, je zde souvislost ?" . "Popisujeme pacientku, kter\u00E1 byla sledov\u00E1na a ne\u00FAsp\u011B\u0161n\u011B l\u00E9\u010Dena pro IgA pemphigus p\u0159i monoklon\u00E1ln\u00ED gamapatii nejist\u00E9ho v\u00FDznamu cyklofosfamidem a dexametazonem, pozd\u011Bji 6 aplikacemi rituximabu. \u017D\u00E1dn\u00FD z uveden\u00FDch l\u00E9\u010Debn\u00FDch postup\u016F nevedl k dlouhodob\u011Bj\u0161\u00EDmu \u00FAstupu IgA pemhigu. V roce 2007 byla zji\u0161t\u011Bna transformace monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho p\u016Fvodu v mnoho\u010Detn\u00FD myelom. Inici\u00E1ln\u00ED l\u00E9\u010Dba cyklofosfamid, adriamycin a dexametazon nevedla k l\u00E9\u010Debn\u00E9 odpov\u011Bdi. Pro l\u00E9\u010Dbu druh\u00E9 linie byla zvolena kombinace thalidomidu cyklofosfamidu a dexametazonu. V pr\u016Fh\u011Bhu prvn\u00EDch t\u00FDdn\u016F t\u00E9to l\u00E9\u010Dby se v\u00FDrazn\u011B zhor\u0161ily ko\u017En\u00ED projevy a\u017E do obrazu erytrodermie. V r\u00E1mci t\u0159et\u00ED linie l\u00E9\u010Dby byla v kv\u011Btnu 2008 zah\u00E1jena l\u00E9\u010Dba bortezomibem, cyklofosfamidem a dexametazonu. Tato l\u00E9\u010Dba vedla ke kompletn\u00ED remisi nemoci a k \u00FApln\u00E9mu vymizen\u00ED morf IgA pemphigu, tak\u017Ee nyn\u00ED je pan\u00ED rok od zah\u00E1jen\u00ED l\u00E9\u010Dby v kompletn\u00ED remisi myelomu a bez zn\u00E1mek IgA pemphigu." . . . "RIV/00216224:14110/10:00046836!RIV11-MSM-14110___" . "8"^^ . "Feit, Josef" . "1802-2960" . . "Pour, Lud\u011Bk" . "Popisujeme pacientku, kter\u00E1 byla sledov\u00E1na a ne\u00FAsp\u011B\u0161n\u011B l\u00E9\u010Dena pro IgA pemphigus p\u0159i monoklon\u00E1ln\u00ED gamapatii nejist\u00E9ho v\u00FDznamu cyklofosfamidem a dexametazonem, pozd\u011Bji 6 aplikacemi rituximabu. \u017D\u00E1dn\u00FD z uveden\u00FDch l\u00E9\u010Debn\u00FDch postup\u016F nevedl k dlouhodob\u011Bj\u0161\u00EDmu \u00FAstupu IgA pemhigu. V roce 2007 byla zji\u0161t\u011Bna transformace monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho p\u016Fvodu v mnoho\u010Detn\u00FD myelom. Inici\u00E1ln\u00ED l\u00E9\u010Dba cyklofosfamid, adriamycin a dexametazon nevedla k l\u00E9\u010Debn\u00E9 odpov\u011Bdi. Pro l\u00E9\u010Dbu druh\u00E9 linie byla zvolena kombinace thalidomidu cyklofosfamidu a dexametazonu. V pr\u016Fh\u011Bhu prvn\u00EDch t\u00FDdn\u016F t\u00E9to l\u00E9\u010Dby se v\u00FDrazn\u011B zhor\u0161ily ko\u017En\u00ED projevy a\u017E do obrazu erytrodermie. V r\u00E1mci t\u0159et\u00ED linie l\u00E9\u010Dby byla v kv\u011Btnu 2008 zah\u00E1jena l\u00E9\u010Dba bortezomibem, cyklofosfamidem a dexametazonu. Tato l\u00E9\u010Dba vedla ke kompletn\u00ED remisi nemoci a k \u00FApln\u00E9mu vymizen\u00ED morf IgA pemphigu, tak\u017Ee nyn\u00ED je pan\u00ED rok od zah\u00E1jen\u00ED l\u00E9\u010Dby v kompletn\u00ED remisi myelomu a bez zn\u00E1mek IgA pemphigu."@cs . . "IgA pemphigus and monoclonal gammopathy, is there a connection ?"@en . . "Krej\u010D\u00ED, Marta" . "IgA pemphigus; bortezomib; rituximab; multiple myeloma; MGUS"@en . "Dermatologie pro praxi" . "8"^^ . . . . "Adam, Zden\u011Bk" . . "IgA pemphigus a monoklon\u00E1ln\u00ED gamapatie, je zde souvislost ?"@cs . . . "Monoclonal gammopathy-associated IgA pemphigus is a debilitating skin disorder with inconsistent response to treatment. A 61-year old female patient with IgA pemphigus and MGUS had been treated unsuccessfully with cyclophosphamide/dexamethasone and then with rituximab. When the monoclonal gammopathy progressed to multiple myeloma, the patient received treatment with cyclophosphamide/doxorubicin/dexamethasone but there was no clinical response. Second-line therapy with thalidomide/cyclophosphamide/dexamethasone combination led to severe exacerbation of the skin disorder. However, therapy with combination regimen that included bortezomib, cyclophosphamide, and dexamethasone resulted in complete and durable remission of multiple myeloma and IgA pemphigus. This suggests that bortezomib-based therapy is useful for the treatment of the rare dermatologic disorder associated with IgA gammopathy and that monoclonal immunoglobulin of IgA class was the cause of IgA pemphigus."@en . "RIV/00216224:14110/10:00046836" . "H\u00E1jek, Roman" . "CZ - \u010Cesk\u00E1 republika" . "\u010Cerm\u00E1kov\u00E1, Zde\u0148ka" . "14110" .