"\u0160up\u00EDkov\u00E1, Jana" . "Transfuze a Hematologie dnes" . "Follicular lymphoma and the significance of its tumour microenvironment."@en . "1213-5763" . . "RIV/00216224:14110/10:00046196" . . "14110" . . "Folikul\u00E1rn\u00ED lymfom a v\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED."@cs . "16" . "S" . . . . "Mayer, Ji\u0159\u00ED" . . "Michalka, Jozef" . "Jan\u00EDkov\u00E1, Andrea" . "3" . . "Folikul\u00E1rn\u00ED lymfom a v\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED." . "6"^^ . . "Follicular lymphoma (FL) is an indolent B mphoproliferative disease characterized by slow growth and recurrent course. Despite of histological homogeneity, clinically, it is quite heterogeneous disease. Median of survival is about 18 years, but 10 to 15% of patients die during 2 to 3 years from the time of diagnosis due to progression of the disease. Spontaneous regressions appear typically in FL and suggest immunological interaction with tumor cells. The importance of the tumor microenvironment as the determining factor of the lymphomas biology is supported by the results of several gene expression and immunophenotyping studies. This review summarizes recent knowledge about the players of the tumor microenvironment in FL such as follicular dendritic cells (FDC), FOXP3+ T regulatory cells (T regs), CD8+ cytotoxic T cells, lymphoma associated macrophages (LAMs), CD57+ NK cells, etc."@en . . "Tich\u00FD, Boris" . . "RIV/00216224:14110/10:00046196!RIV11-MSM-14110___" . . "[795B2846F38B]" . . "259482" . "Fabian, Pavel" . "CZ - \u010Cesk\u00E1 republika" . . . "6"^^ . "Folikul\u00E1rn\u00ED lymfom (FL) je indolentn\u00ED B lymfoproliferace charakterizovan\u00E1 pomal\u00FDm r\u016Fstem a rekurentn\u00EDm pr\u016Fb\u011Bhem. Navzdory histologick\u00E9 uniformit\u011B se klinicky jedn\u00E1 o zna\u010Dn\u011B heterogenn\u00ED onemocn\u011Bn\u00ED. Celkov\u00FD medi\u00E1n p\u0159e\u017Eit\u00ED se pohybuje kolem 18 let, p\u0159esto 10 a\u017E 15 % pacient\u016F um\u00EDr\u00E1 v d\u016Fsledku progrese FL do 2 a\u017E 3 let. Pro FL jsou tak\u00E9 p\u0159\u00EDzna\u010Dn\u00E9 spont\u00E1nn\u00ED regrese, co\u017E p\u0159edpokl\u00E1d\u00E1 imunologickou interakci n\u00E1dorov\u00FDch bun\u011Bk s ostatn\u00EDmi elementy imunitn\u00EDho syst\u00E9mu. V\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED jako ur\u010Duj\u00EDc\u00EDho faktoru chov\u00E1n\u00ED FL podporuj\u00ED v\u00FDsledky studi\u00ED genov\u00E9 exprese a anal\u00FDzy imunofenotypu ne n\u00E1dorov\u00FDch bun\u011Bk. P\u0159edkl\u00E1dan\u00FD p\u0159ehled sumarizuje sou\u010Dasn\u00E9 poznatky o jednotliv\u00FDch hr\u00E1\u010D\u00EDch n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED FL jako jsou folikul\u00E1rn\u00ED dendritick\u00E9 bu\u0148ky (FDC), T-regula\u010Dn\u00ED (FOXP3+) a T cytotoxick\u00E9 lymfocyty (CD8+), s lymfocyty asociovan\u00E9 makrof\u00E1gy (LAM), NK bu\u0148ky (CD57+) apod." . "Folikul\u00E1rn\u00ED lymfom a v\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED." . . . . . . "Folikul\u00E1rn\u00ED lymfom (FL) je indolentn\u00ED B lymfoproliferace charakterizovan\u00E1 pomal\u00FDm r\u016Fstem a rekurentn\u00EDm pr\u016Fb\u011Bhem. Navzdory histologick\u00E9 uniformit\u011B se klinicky jedn\u00E1 o zna\u010Dn\u011B heterogenn\u00ED onemocn\u011Bn\u00ED. Celkov\u00FD medi\u00E1n p\u0159e\u017Eit\u00ED se pohybuje kolem 18 let, p\u0159esto 10 a\u017E 15 % pacient\u016F um\u00EDr\u00E1 v d\u016Fsledku progrese FL do 2 a\u017E 3 let. Pro FL jsou tak\u00E9 p\u0159\u00EDzna\u010Dn\u00E9 spont\u00E1nn\u00ED regrese, co\u017E p\u0159edpokl\u00E1d\u00E1 imunologickou interakci n\u00E1dorov\u00FDch bun\u011Bk s ostatn\u00EDmi elementy imunitn\u00EDho syst\u00E9mu. V\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED jako ur\u010Duj\u00EDc\u00EDho faktoru chov\u00E1n\u00ED FL podporuj\u00ED v\u00FDsledky studi\u00ED genov\u00E9 exprese a anal\u00FDzy imunofenotypu ne n\u00E1dorov\u00FDch bun\u011Bk. P\u0159edkl\u00E1dan\u00FD p\u0159ehled sumarizuje sou\u010Dasn\u00E9 poznatky o jednotliv\u00FDch hr\u00E1\u010D\u00EDch n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED FL jako jsou folikul\u00E1rn\u00ED dendritick\u00E9 bu\u0148ky (FDC), T-regula\u010Dn\u00ED (FOXP3+) a T cytotoxick\u00E9 lymfocyty (CD8+), s lymfocyty asociovan\u00E9 makrof\u00E1gy (LAM), NK bu\u0148ky (CD57+) apod."@cs . "Follicular lymphoma and the significance of its tumour microenvironment."@en . "8"^^ . "follicular lymphoma; t(14; 18); tumor microenvironment; FOXP3; follicular dendritic cells; lymphoma associated macrophages"@en . . . . "Folikul\u00E1rn\u00ED lymfom a v\u00FDznam n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED."@cs .