. . . . . "4"^^ . . "Treatment of resistant schizophrenia in clinical practice"@en . . . "P\u0159ikryl, Radovan" . . "[A4C67B2DD3E6]" . . "14110" . "Treatment of resistant schizophrenia in clinical practice"@en . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie v praxi"@cs . . . "4" . "Treatment of resistant schizophrenia is a serious medical problem. Although it does not exist its common definition, its main criterium is failure of two treatment trials with antipsychotics from two different chemical classes in sufficient dosage and duration. The article deals with possibilities of pseudoresistance, especially false diagnosis, comorbidity, insufficient treatment trials and non-compliance. In the case of treatment-resistant schizophrenia we have several treatment strategies, which can be divided into pharmacological and nonpharmacological methods. The key position keeps clozapine, vhich efficacy was confirmed repeatedly. Another treatment possibillities consist of combination of antipsychotics, their augmentation and then nonpharmacological strategies, especially electroconvulsive therapy, experimentally used repetitive transcranial magnetic stimulation and also psychotherapy."@en . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie v praxi" . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie pat\u0159\u00ED mezi z\u00E1va\u017En\u00E9 medic\u00EDnsk\u00E9 probl\u00E9my. I kdy\u017E jednotn\u00E1 definice rezistentn\u00ED schizofrenie neexistuje, nej\u010Dast\u011Bji se za jej\u00ED krit\u00E9rium pova\u017Euje selh\u00E1n\u00ED dvou l\u00E9\u010Debn\u00FDch pokus\u016F veden\u00FDch antipsychotiky ze dvou r\u016Fzn\u00FDch chemick\u00FDch skupin v dostate\u010Dn\u00E9 d\u00E1vce pro dostate\u010Dnou dobu. \u010Cl\u00E1nek se zab\u00FDv\u00E1 mo\u017Enostmi pseudorezistence, ke kter\u00FDm pat\u0159\u00ED zejm\u00E9na chybn\u00E1 diagn\u00F3za, nerozpoznan\u00E1 komorbidita, nedostate\u010Dnost l\u00E9\u010Debn\u00FDch pokus\u016F a noncompliance ze strany pacienta. V p\u0159\u00EDpad\u011B potvrzen\u00ED rezistence existuje n\u011Bkolik terapeutick\u00FDch mo\u017Enost\u00ED, kter\u00E9 lze d\u011Blit na farmakologick\u00E9 a nefarmakologick\u00E9. Mezi farmakologick\u00FDmi metodami si kl\u00ED\u010Dovou pozici udr\u017Euje nasazen\u00ED klozapinu, jeho\u017E \u00FA\u010Dinnost byla opakovan\u011B ov\u011B\u0159ena. K dal\u0161\u00EDm mo\u017Enostem pat\u0159\u00ED p\u0159edev\u0161\u00EDm kombinace antipsychotik, jejich augmentace a z nefarmakologick\u00FDch pak elektrokonvulzivn\u00ED terapie, experiment\u00E1ln\u011B u\u017E\u00EDvan\u00E1 repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E1 stimulace a d\u00E1le psychoterapie." . . . . "RIV/00216224:14110/09:00036264!RIV10-MSM-14110___" . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie pat\u0159\u00ED mezi z\u00E1va\u017En\u00E9 medic\u00EDnsk\u00E9 probl\u00E9my. I kdy\u017E jednotn\u00E1 definice rezistentn\u00ED schizofrenie neexistuje, nej\u010Dast\u011Bji se za jej\u00ED krit\u00E9rium pova\u017Euje selh\u00E1n\u00ED dvou l\u00E9\u010Debn\u00FDch pokus\u016F veden\u00FDch antipsychotiky ze dvou r\u016Fzn\u00FDch chemick\u00FDch skupin v dostate\u010Dn\u00E9 d\u00E1vce pro dostate\u010Dnou dobu. \u010Cl\u00E1nek se zab\u00FDv\u00E1 mo\u017Enostmi pseudorezistence, ke kter\u00FDm pat\u0159\u00ED zejm\u00E9na chybn\u00E1 diagn\u00F3za, nerozpoznan\u00E1 komorbidita, nedostate\u010Dnost l\u00E9\u010Debn\u00FDch pokus\u016F a noncompliance ze strany pacienta. V p\u0159\u00EDpad\u011B potvrzen\u00ED rezistence existuje n\u011Bkolik terapeutick\u00FDch mo\u017Enost\u00ED, kter\u00E9 lze d\u011Blit na farmakologick\u00E9 a nefarmakologick\u00E9. Mezi farmakologick\u00FDmi metodami si kl\u00ED\u010Dovou pozici udr\u017Euje nasazen\u00ED klozapinu, jeho\u017E \u00FA\u010Dinnost byla opakovan\u011B ov\u011B\u0159ena. K dal\u0161\u00EDm mo\u017Enostem pat\u0159\u00ED p\u0159edev\u0161\u00EDm kombinace antipsychotik, jejich augmentace a z nefarmakologick\u00FDch pak elektrokonvulzivn\u00ED terapie, experiment\u00E1ln\u011B u\u017E\u00EDvan\u00E1 repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E1 stimulace a d\u00E1le psychoterapie."@cs . . "10" . "CZ - \u010Cesk\u00E1 republika" . "1213-0508" . "RIV/00216224:14110/09:00036264" . . "2"^^ . "Ustohal, Libor" . . . "Psychiatrie pro praxi" . "treatment resistant schizophrenia; clozapine; combination of antipsychotics; augmentation of antipsychotics; ECT; rTMS"@en . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie v praxi"@cs . "Z(MSM0021622404)" . "L\u00E9\u010Dba rezistentn\u00ED schizofrenie v praxi" . "2"^^ . "323466" .