. "Mr\u00E1z, Marek" . . "CZ - \u010Cesk\u00E1 republika" . "MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene)."@en . . "Mayer, Ji\u0159\u00ED" . "MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene)." . "50" . . "000265361100040" . "LEUKEMIA & LYMPHOMA" . . . "Plevov\u00E1, Karla" . "P(NR9293), Z(MSM0021622430)" . "326207" . . . . "3" . "MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype." . "RIV/00216224:14110/09:00035765" . . "1042-8194" . "14110" . . "RIV/00216224:14110/09:00035765!RIV11-MZ0-14110___" . "Posp\u00ED\u0161ilov\u00E1, \u0160\u00E1rka" . . "MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype."@en . . . "MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype."@en . . "\u0160lap\u00E1k, Ivo" . "[6AA9A1EFEF98]" . . "MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype." . . . . . "5"^^ . . "4"^^ . . "CLL; p53; miR-34a; miR-29c; miR-17-5p"@en . "5"^^ . .